Distribution and sample immunohistochemical images of MCM3 expression in primary and metastatic melanoma. Distribution of immunohistochemical MCM3 expression denoted as the multiplier of fraction and intensity of staining (nuclear score = NS) in a) primary melanoma and b) metastases. Sample images of MCM3 expression in primary tumour and paired metachronous metastasis: c) nodular melanoma on left ear (NS = 2) and d) lymph node metastasis in left groin (NS = 0); e) superficial spreading melanoma on lower left leg (NS = 6) and g) cutaneous metastasis on back of neck (NS = 4); nodular melanoma on lower right leg (NS = 6) and cutaneous metastasis on lower right leg (NS = 9).
Nodin et al. Diagnostic Pathology 2012 7:82 doi:10.1186/1746-1596-7-82