Figure 3.

Immunohistochemical staining of a needle biopsy containing an area of prostatic intra-epithelial neoplasia (PIN) with the two-marker cocktail. Prostate glands show staining both in the cytoplasm of luminal epithelial cells (brown granular AMACR-positive staining) and in the nuclei of basal epithelial cells (brown nuclear p63-positive staining). This reaction pattern is characteristic for PIN (x 100).