Immunohistochemical staining of a needle biopsy containing an area of prostatic intra-epithelial neoplasia (PIN) with the two-marker cocktail. Prostate glands show staining both in the cytoplasm of luminal epithelial cells (brown granular AMACR-positive staining) and in the nuclei of basal epithelial cells (brown nuclear p63-positive staining). This reaction pattern is characteristic for PIN (x 100).
Dabir et al. Diagnostic Pathology 2012 7:81 doi:10.1186/1746-1596-7-81