Photomicrographs show immunohistochemical reactions of EGFR, MGMT and DNMT antibodies. Recurrent anaplastic astrocytoma (case 6) was strong EGFR membrane positive but no reaction in glioblastoma (case 10) (A). MGMT immunostaining of nuclei with a weak cytoplasmic staining in primary glioblatoma (case 11) but no reaction in anaplastic astrocytoma (case 7) (B). Recurrent anaplastic astrocytoma (case 4) was DNMT cytoplasmic positive but no reaction in seconder glioblastoma (case 8) (C).
Gömöri et al. Diagnostic Pathology 2012 7:8 doi:10.1186/1746-1596-7-8