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Peripheral T-cell Lymphoma with Cyclin D1 overexpression: a case report

Gabriella Aquino1, Renato Franco1*, Fioravante Ronconi23, Annamaria Anniciello1, Luigi Russo1, Annarosaria De Chiara1 and Luigi Panico4

Author Affiliations

1 Pathology Unit, National Cancer Institute “Fondazione Giovanni Pascale”, Via Mariano Semmola, 80131, Napoli, Italy

2 Hematology Unit, Hospital “S.G .Moscati”, Contrada Amoretta, 83100, Avellino, Italy

3 Hematology Unit, Hospital “Caradarelli”, Naples, Italy

4 Pathology Unit, Hospital “S.G .Moscati”, Contrada Amoretta, 83100, Avellino, Italy

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Diagnostic Pathology 2012, 7:79  doi:10.1186/1746-1596-7-79

Published: 6 July 2012


Peripheral T-cell lymphomas not otherwise specified are generally considered aggressive non-Hodgkin lymphomas, because of poor natural outcome and response to therapy. They show a complex karyotype without any specific genetic hallmark. We report a case of peripheral T-cell lymphoma not otherwise specified with heterogeneous nuclear Cyclin D1 immunohistochemical overexpression, due to gene copy gain, a phenomenon similar to that observed in Mantle Cell Lymphoma characterized by t(11;14)(q13;q32). In this case report we underline the diagnostic pitfall rapresented by Cyclin D1 immunoistochemical overexpression in a T-cell lymphoma. Several pitfalls could lead to misinterpretation of diagnosis, therefore, we underlined the need to integrate the classical histology and immunohistochemistry with molecular tests as clonality or Fluorescence in situ hybridization.

Virtual slide

The virtual slides for this article can be found here:

CCND1 copy gain; Cyclin D1 over-expression; Peripheral T-cell lymphoma; FISH