Table 3

Immunohistochemical strategies, statistical results
Strategy TP TN FP FN S (%) Sp (%) PPV (%) +LR −LR
Markers considered in a parallel manner
1 HR + CK7 + P-15 10 42 0 19 35 100 100 999.999 0.66
2 HR + CK7 + P-15 + MAG 7 42 0 22 24 100 100 999.999 0.76
Markers considered in a serial manner
3 HR----CK7 28 20 22 1 97 48 56 1.84 0.07
4 HR----MAG 21 39 3 9 70 93 88 9.80 0.32
5 HR----MAG----CK7 28 22 20 1 97 52 58 2.03 0.07

HR: estrogen and progesterone receptors; CK7: cytokeratin 7; P-15: gross cystic disease fluid protein (GCDFP-15); MAG: mammaglobin; TP: true positives; TN: true negatives; FP: false positive; FN: false negative; S: sensitivity; Sp: specificity; PPV: positive predictive value; + LR: positive likelihood ratio; − LR: negative likelihood ratio.

Noriega et al.

Noriega et al. Diagnostic Pathology 2012 7:73   doi:10.1186/1746-1596-7-73

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