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Primary Intravascular large B-cell lymphoma of lung: a report of one case and review

Hui Yu1, Gang Chen124*, Rongxuan Zhang1 and Xiaolong Jin3

Author Affiliations

1 Department of Pathology, Shanghai Pulmonary Hospital Tongji University School of Medicine, Shanghai, China

2 Department of Pathology, Tongji University School of Medicine, Shanghai, China

3 Department of Pathology, Ruijin Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, China

4 Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zhengmin Road, Shanghai, China

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Diagnostic Pathology 2012, 7:70  doi:10.1186/1746-1596-7-70

Published: 20 June 2012



To investigate the clinicopathological features of primary intravascular large B-cell lymphoma of lung.


A case of primary pulmonary intravascular large B-cell lymphoma was analysed in histopathology and immunophenotype.


The patient is a 42-year-old female who had cough for one year. Computed tomography showed ground-glass opacities and small nodules in bilateral lung fields. Histopathology demonstrated accumulation of similar sized neoplastic cells within alveolar capillaries, widening the alveolar septae. The alveolar structure sustained in part of districtions. Immunohistologically, the tumor cells were positive for CD20 and negative for CD3,CK, which were similar to the diffuse large B-cell lymphoma.


Intravascular large B-cell lymphoma is an uncommon type of non-Hodgkin’s lymphoma. Primary pulmonary presentation is even more rare. The diagnosis is based on the histopathology and immunohistochemistry.

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Intravascular large B-cell lymphoma; Primary; Lung; Clinicopathology