Multiple gene amplifications detected with MLPA in GBM1-4 shown as line graphs of peak heights. MLPA results for genes in tumors were compared with non-neoplastic (or normal) brain DNA. Heights of peaks reflected amounts of genes, or their CN. Mid to high-level gene amplifications were obvious by visual inspection of peak heights (mm) for at least one gene in each glioblastoma. These are labelled and also asterisks indicate these genes along the x-axes. Line graphs connecting the peak heights are colored according to the legends. Tumor and normal brain (NB) were tested concurrently.
Truong et al. Diagnostic Pathology 2012 7:66 doi:10.1186/1746-1596-7-66