Photomicrographs of the osseous lesion. (a) Scattered lacunar cells were observed in the inflammatory background with numerous lymphocytes, histiocytes, and eosinophilic granulocytes. (b) Typical morphology of Reed-Sternberg cells, with large cytoplasms and prominent eosinophilic nucleoli were also found in the lesion (white arrow). The immunohistochemical staining of the RS cells confirmed the expression of CD30 (c) and CD15 (d) with typical membrane and paranuclear dot-like staining pattern (a-b, HE staining with original magnification × 400; c-d, immunohistochemical staining with original magnification × 400).
Li et al. Diagnostic Pathology 2012 7:64 doi:10.1186/1746-1596-7-64