Table 6 |
||||
| Gene-protein BISH (comparator)vs.single BISH (reference) agreement analyses | ||||
| Single BISH | ||||
| Gene-protein BISH | Amplified | Non-amplified | Total | |
| Reader A | Amplified | 43 | 2 | 45 |
| Non-amplified | 2 | 118 | 120 | |
| Total | 45 | 120 | 165 | |
| PPA: n/N (%) (95% CI) | 43/45 (95.6) (85.2–98.8) | |||
| NPA: n/N (%) (95% CI) | 118/120 (98.3) (94.1–99.5) | |||
| OPA: n/N (%) (95% CI) | 161/165 (97.6) (93.9–99.1) | |||
| Kappa coefficient (95% CI) | 0.94 (0.88–1.00) | |||
| Reader B | Amplified | 47 | 1 | 48 |
| Non-amplified | 3 | 121 | 124 | |
| Total | 50 | 122 | 172 | |
| PPA: n/N (%) (95% CI) | 47/50 (94.0) (83.8–97.9) | |||
| NPA: n/N (%) (95% CI) | 121/122 (99.2) (95.5–99.9) | |||
| OPA: n/N (%) (95% CI) | 168/172 (97.7) (94.2–99.1) | |||
| Kappa coefficient (95% CI) | 0.94 (0.89–1.00) | |||
| Reader C | Amplified | 41 | 5 | 46 |
| Non-amplified | 2 | 125 | 127 | |
| Total | 43 | 130 | 173 | |
| PPA: n/N (%) (95% CI) | 41/43 (95.3) (84.5–98.7) | |||
| NPA: n/N (%) (95% CI) | 125/130 (96.2) (91.3–98.3) | |||
| OPA: n/N (%) (95% CI) | 166/173 (96.0) (91.9–98.0) | |||
| Kappa coefficient (95% CI) | 0.89 (0.82–0.97) | |||
BISH: brightfield in situ hybridization; PPA: positive percent agreement; NPA: negative percent agreement; OPA: overall percent agreement.
Nitta et al. Diagnostic Pathology 2012 7:60 doi:10.1186/1746-1596-7-60
