Table 5 |
||||
| Gene-protein IHC (comparator)vs.single IHC (reference) agreement analyses | ||||
| Single IHC | ||||
| Gene-protein IHC | Positive | Negative | Total | |
| Reader A | Positive | 50 | 2 | 52 |
| Negative | 0 | 131 | 131 | |
| Total | 50 | 133 | 183 | |
| PPA: n/N (%) (95% CI) | 50/50 (100.0) (92.9–100.0) | |||
| NPA: n/N (%) (95% CI) | 131/133 (98.5) (94.7–99.6) | |||
| OPA: n/N (%) (95% CI) | 181/183 (98.9) (96.1–99.7) | |||
| Kappa coefficient (95% CI) | 0.97 (0.94–1.00) | |||
| Reader B | Positive | 47 | 3 | 50 |
| Negative | 1 | 132 | 133 | |
| Total | 48 | 135 | 183 | |
| PPA: n/N (%) (95% CI) | 47/48 (97.9) (89.1–99.6) | |||
| NPA: n/N (%) (95% CI) | 132/135 (97.8) (93.7–99.2) | |||
| OPA: n/N (%) (95% CI) | 179/183 (97.8) (94.5–99.1) | |||
| Kappa coefficient (95% CI) | 0.94 (0.89–1.00) | |||
| Reader C | Positive | 54 | 1 | 55 |
| Negative | 0 | 128 | 128 | |
| Total | 54 | 129 | 183 | |
| PPA: n/N (%) (95% CI) | 54/54 (100.0) (93.4–100.0) | |||
| NPA: n/N (%) (95% CI) | 128/129 (99.2) (95.7–99.9) | |||
| OPA: n/N (%) (95% CI) | 182/183 (99.5) (97.0–99.9) | |||
| Kappa coefficient (95% CI) | 0.99 (0.96–1.00) | |||
IHC: immunohistochemistry; PPA: positive percent agreement; NPA: negative percent agreement; OPA: overall percent agreement.
Nitta et al. Diagnostic Pathology 2012 7:60 doi:10.1186/1746-1596-7-60
