Table 4

BISH descriptive statistics
Reader A Reader B Reader C
Gene-protein BISH (N = 183) Single BISH (N = 183) Gene-protein BISH (N = 183) Single BISH (N = 183) Gene-protein BISH (N = 183) Single BISH (N = 183)
HER2mean
n 179 166 179 172 180 173
Mean (SD) 4.273 (4.208) 4.643 (4.567) 5.199 (6.280) 5.452 (6.693) 3.333 (2.851) 3.176 (2.362)
Median 2.200 2.225 1.900 1.900 2.000 1.950
Min, max 1.00, 21.10 1.00, 22.60 1.00, 40.20 1.00, 40.40 1.00, 16.25 1.20, 11.10
CEN17 mean
n 179 166 179 172 180 173
Mean (SD) 1.803 (0.496) 1.868 (0.501) 1.566 (0.356) 1.540 (0.339) 1.606 (0.335) 1.613 (0.296)
Median 1.650 1.750 1.500 1.450 1.550 1.550
Min, max 1.00, 3.50 1.00, 3.95 1.00, 2.80 1.00, 2.95 1.05, 2.60 1.00, 2.65
HER2/CEN17 ratio
n 179 166 179 172 180 173
Mean (SD) 2.485 (2.613) 2.521 (2.533) 3.344 (3.952) 3.637 (4.620) 2.100 (1.802) 2.004 (1.564)
Median 1.170 1.190 1.310 1.355 1.255 1.240
Min, max 0.67, 10.82 0.76, 11.02 0.67, 19.14 0.60, 26.06 0.74, 8.46 0.82, 9.25
Amplification status, n (%)
Amplified 46 (25.1) 46 (25.1) 49 (26.8) 50 (27.3) 47 (25.7) 43 (23.5)
Non-amplified 133 (72.7) 120 (65.6) 130 (71.0) 122 (66.7) 133 (72.7) 130 (71.0)
N/A 4 (2.2) 17 (9.3) 4 (2.2) 11 (6.0) 3 (1.6) 10 (5.5)

BISH: brightfield in situ hybridization; HER2: human epidermal growth factor receptor 2; CEN17: chromosome 17 centromere.

Nitta et al.

Nitta et al. Diagnostic Pathology 2012 7:60   doi:10.1186/1746-1596-7-60

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