Photomicrographs of the renal biopsy specimen. ( A) A low power view showing the diffuse distribution of sclerotic glomeruli with or without various stages of crescents. ( B and C) Two sections of the same glomerulus with a cellular crescent. (Upper panel, Periodic acid-Schiff stain; Lower panel, Silver Methenamine-Masson trichrome stain) ( D) Immunohistochemical staining with an anti-serum specific for IgM showed focal entrapment in the depending portions of the areas of hyalinosis. ( E) An electron micrograph showing a portion of the glomerulus indicating an amorphous electron-dense material presumably representing hyalinosis or nonimmunologic deposition of plasma proteins (*). The scale or scale bar is indicated in each panel.
Otani et al. Diagnostic Pathology 2012 7:46 doi:10.1186/1746-1596-7-46