Open Access Case Report

Is there a link between diabetic glomerular injury and crescent formation? A case report and literature review

Naoko Otani1, Tetsu Akimoto1*, Wako Yumura1, Daisuke Matsubara2, Yoshitaka Iwazu1, Akihiko Numata1, Takuya Miki1, Fumi Takemoto1, Noriyoshi Fukushima2, Shigeaki Muto1 and Eiji Kusano1

Author affiliations

1 Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-Shi, TOCHIGI, 329-0498, JAPAN

2 Department of Integrative Pathology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-Shi, TOCHIGI, 329-0498, JAPAN

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Citation and License

Diagnostic Pathology 2012, 7:46  doi:10.1186/1746-1596-7-46

Published: 20 April 2012

Abstract

Glomerular crescents are most commonly associated with rapidly progressive crescentic glomerulonephritis; however, they also develop in response to a wide range of primary and secondary glomerular injuries. Since various kind of glomerulopathies occasionally overlay diabetic glomerular injuries, the presence of crescents in renal biopsy specimens of diabetics may have stimulated a search for etiologies other than diabetes. In this report, we describe an unusual case of diabetic glomerulosclerosis with peculiar extracapillary proliferation. Although such a relationship has so far been ignored in most of the literature, the etiological linkage between diabetic glomerulosclerosis and the development of crescents may not be exceptional. We have reviewed the previous literature and herein discuss the pathological implications of the development of crescents in patients with diabetic glomerulosclerosis.

Virtual slides

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/3950457896920255 webcite.

Keywords:
Diabetes; Diabetic glomerulosclerosis; Glomerular crescent; Hyalinosis; Exudative lesion; Renal biopsy