Table 5

Comparison of cytological analysis and the FISH test for CIN2+ diagnosis

Test method

Cytological analysis

FISH test


Cut-off value†

ASCUS+

TERC+

C-MYC+

TERC + and C-MYC+

TERC + or C-MYC+


Sensitivity, % (95%CI)

84.0 (73.8-94.2)

90.0(81.7-98.3)

80.0 (68.9-91.2)

78.0 (66.5-89.5)

92.0 (84.5-99.5)

Specificity, % (95%CI)

64.3(57.5-71.0)

89.6(85.3-93.9)

77.7 (71.8-83.6)

95.3 (92.3-98.3)

72.0 (65.7-78.3)

PPV, % (95%CI)

37.8(28.8-46.9)

69.2(58.0-80.5)

48.2 (37.5-59.0)

81.3 (70.3-92.3)

46.0 (36.2-55.8)

NPV, % (95%CI)

93.9(89.9-98.0)

97.2(94.8-99.6)

93.8 (90.1-97.5)

94.4 (91.2-97.6)

97.2 (94.5-99.9)

Accuracy, % (95%CI)

68.3(62.5-74.2)

89.7(85.9-93.5)

78.2 (73.0-83.4)

91.8 (88.4-95.3)

76.1 (70.7-81.5)

Youden's index, % (95%CI)

48.3(31.3-65.2)

79.6(67.0-92.3)

57.7 (40.7-74.8)

73.3 (58.8-87.5)

64.0 (50.2-77.8)


† Cut-off value: ASCUS + determined as ASCUS or higher. TERC + determined as ≥ 5% aberrant TERC cells among all of the cells observed. C-MYC + determined as ≥ 3% aberrant C-MYC cells among all of the cells observed

Chen et al. Diagnostic Pathology 2012 7:40   doi:10.1186/1746-1596-7-40

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