Representative images of probe set TERC -CEP3 and C-MYC signals observed in cervical epithelial cells. A: Normal TERC-CEP3 signal pattern of 2-2 (patterns are described in the order TERC-CEP3). B: Normal C-MYC signal pattern with 2 signals in each nucleus. C: A 7-4 pattern cell of TERC-CEP3 hybridization is shown at the bottom. The cytological diagnosis was LSIL, whereas the histological diagnosis was CIN2. D: A 4-signal cell of C-MYC hybridization is shown at the left. The cytological diagnosis was HSIL, but the histological diagnosis was CIN1. E: A 7-7 signal pattern cell from a HSIL patient. The histological diagnosis was CIN3. F: Two 7-signal cells that lay next to each other in an HSIL patient. The histological diagnosis was CIN3.
Chen et al. Diagnostic Pathology 2012 7:40 doi:10.1186/1746-1596-7-40