Table 2

Clinicopathological characteristics of the reported sporadic hemangioblastomas in the kidney

Case

Age(y)/Sex

Gross features

Histological features

Immunohistochemical staining

Treatment/Follow-up(y)


Cytoplasm

Nuclear

Necrosis

Stromal fibrosis

Diffuse

Focal


1(ref.4)

71/female

Solid with scattered cystic spaces; located in right kidney

Amphophilic to clear

Round with delicate chromatin; lack of mitoses

Absent

Present

a-inhibin

Vimentin, S100, SMA, MSA, calponin

NP/AW/9

2(ref.5)

58/male

Solid with a cystic cavity; located in right kidney

Eosinophilic

Mildly to highly pleomorphic; lack of mitoses

Absent

Present

a-inhibin, S100, NSE, GLUT1

NP/AW/2

3(ref.5)

55/female

Solid; located in right kidney

Eosinophilic; variable-sized hyaline globules were found

Mildly to highly pleomorphic; very sparse mitoses

Present

Present

a-inhibin, S100, NSE, GLUT1

NP/AW/4

4(ref.6)

64/male

Solid; located in left kidney

Weakly eosinophilic

Enlarged and slightly atypical; lack of mitoses

Absent

Present

S100, NSE, Vimentin

EMA, a-inhibin

pNP/AW/4

5(present case)

61/male

Solid; located in right kidney

Eosinophilic; exhibiting a rhabdoid phenotype

Mildly to highly pleomorphic; intranuclear cytoplasmic pseudoinclusions were present; sparse mitoses

Present

Present

a-inhibin, S100, NSE, EGFR

CD10, EMA

NP/AW/1


NP, nephrectomy; pNP, partial nephrectomy; AW, alive and well

Yin et al. Diagnostic Pathology 2012 7:39   doi:10.1186/1746-1596-7-39

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