Figure 1.

Histopathological findings of the renal hemangioblastoma. (A) Stromal hyalinization was prominent among the neoplasm and foci of necrosis were observed inside the tumor (left field) (H&E staining, with original magnification ×40). (B) The tumor cells were arranged in nests and traversed by a vascular network (H&E staining, with original magnification ×100). (C) Lipid vesicles were abundant in some tumor cells (H&E staining, with original magnification ×400). (D) The tumor cells had enlarged eosinophilic cytoplasm and eccentrically-displaced nuclei, exhibiting a rhabdoid phenotype (H&E staining, with original magnification ×200). (E) Pseudo-nuclear invaginations were another distinctive feature of tumor cells (H&E staining, with original magnification ×400). (F) The sclerotic stroma dispersed tumor cells into isolated small nests (H&E staining, with original magnification ×100). The vessels in between were usually dilated and some of them resembled the changes of papillary endothelial hyperplasia (inserted panel, H&E staining, with original magnification ×400).