Representative photomicrographs. Immunohistochemical expressions for claudin-6, methy-CpG binding protein 2 (MeCP2) and DNA methyltransferase 1 (DNMT1) in breast invasive ductal carcinomas (IDC) and fibroadenomas (FA) (×400). (A) claudin-6 was expressed in breast adenoma cells. Note: the staining on membrane (dotted arrow); the staining in cytoplasm (solid arrow). (B) claudin-6 was weakly expressed in IDC cells. (C) MeCP2 immunoreactivity was moderate in the FA tissues (arrow). (D), (F) MeCP2 and DNMT1 were strongly expressed in breast IDC cells, especially at the nuclear (arrow). (E) DNMT1 immunoreactivity was not detected in the breast FA tissues.
Xu et al. Diagnostic Pathology 2012 7:33 doi:10.1186/1746-1596-7-33