Table 5

Staining Scores in SMPC, AMPC and nMPC lesions

Classification/Antibody

SMPC

AMPC

nMPC


Cellular adhesion molecules

E-cadherin

215.3*

143.9

187.1

CD44

60.8

205.9

141.3

Laminin5γ2

69.4

36.9

60.3

Growth factor

VEGF-C

294.4

296.4

282.1

Apoptosis-associated proteins

bcl2

13.2

11.1

21.8

p53§

36.4

26.1

45.0

cleaved caspase-3§

0.3

0.2

0.4

Mucin-related proteins

MUC1

169.7

182.5

202.1

MUC6

0.0

0.0

0.0

Hypoxia induced protein

HIF-1α

1.8

2.4

2.9

Others

TTF-1

267.9

289.3

248.6

SP-A

45.2

82.6

123.2

Vimentin

112.1

117.9

72.1

Ki-67§

22.6

16.9

16.2

LYVE1

98.9

107.2

101.9

c-Met

217.2

253.8

211.4

Phospho-c-Met

34.2

50.0

88.0


SMPC, stromal micropapillary component; AMPC, aerogeneous micropapillary component; nMPC, non-micropapillary component; VEGF-C, vascular endothelial growth factor-C; HIF-1α, hypoxia induced factor 1-α; TTF-1, thyroid transcription factor-1; SP-A, surfactant apoprotein A; LYVE1, lymphatic vessel endothelial hyaluronan receptor 1.

§ Positivity rate of positive tumor cells in 300 tumor cells (percentage).

* The difference in staining scores between SMPC and AMPC is statistically significant (P = 0.020).

‡ The differences in staining scores between SMPC and nMPC are statistically significant for CD44 (P = 0.011), and SP-A (P = 0.024) and phospho-c-Met (P = 0.011) expression.

¶ The difference in staining scores between AMPC and nMPC is statistically significant (P = 0.015).

Ohe et al. Diagnostic Pathology 2012 7:3   doi:10.1186/1746-1596-7-3

Open Data