Table 5 |
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|
Staining Scores in SMPC, AMPC and nMPC lesions |
|||
|
Classification/Antibody |
SMPC |
AMPC |
nMPC |
|
|
|||
|
Cellular adhesion molecules |
|||
|
E-cadherin |
215.3* |
143.9 |
187.1 |
|
CD44 |
60.8‡ |
205.9¶ |
141.3 |
|
Laminin5γ2 |
69.4 |
36.9 |
60.3 |
|
Growth factor |
|||
|
VEGF-C |
294.4 |
296.4 |
282.1 |
|
Apoptosis-associated proteins |
|||
|
bcl2 |
13.2 |
11.1 |
21.8 |
|
p53§ |
36.4 |
26.1 |
45.0 |
|
cleaved caspase-3§ |
0.3 |
0.2 |
0.4 |
|
Mucin-related proteins |
|||
|
MUC1 |
169.7 |
182.5 |
202.1 |
|
MUC6 |
0.0 |
0.0 |
0.0 |
|
Hypoxia induced protein |
|||
|
HIF-1α |
1.8 |
2.4 |
2.9 |
|
Others |
|||
|
TTF-1 |
267.9 |
289.3 |
248.6 |
|
SP-A |
45.2‡ |
82.6 |
123.2 |
|
Vimentin |
112.1 |
117.9 |
72.1 |
|
Ki-67§ |
22.6 |
16.9 |
16.2 |
|
LYVE1 |
98.9 |
107.2 |
101.9 |
|
c-Met |
217.2 |
253.8 |
211.4 |
|
Phospho-c-Met |
34.2‡ |
50.0 |
88.0 |
|
|
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|
SMPC, stromal micropapillary component; AMPC, aerogeneous micropapillary component; nMPC, non-micropapillary component; VEGF-C, vascular endothelial growth factor-C; HIF-1α, hypoxia induced factor 1-α; TTF-1, thyroid transcription factor-1; SP-A, surfactant apoprotein A; LYVE1, lymphatic vessel endothelial hyaluronan receptor 1. § Positivity rate of positive tumor cells in 300 tumor cells (percentage). * The difference in staining scores between SMPC and AMPC is statistically significant (P = 0.020). ‡ The differences in staining scores between SMPC and nMPC are statistically significant for CD44 (P = 0.011), and SP-A (P = 0.024) and phospho-c-Met (P = 0.011) expression. ¶ The difference in staining scores between AMPC and nMPC is statistically significant (P = 0.015). |
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|
Ohe et al. Diagnostic Pathology 2012 7:3 doi:10.1186/1746-1596-7-3 |
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