Table 1

Patient and tumour characteristics

Intrinsic subtype


Luminal A

Luminal B

Luminal B HER2+

HER2+

Triple-negative

p


Age group

n.s

Age < 55 year (n = 52)

17 (40)

14 (52)

8 (53)

1 (17)

12 (67)

Age > 55 year (n = 57)

26 (60)

13 (48)

7 (47)

5 (83)

6 (33)

Histological grade

< 0.0001

1

16 (37)

2 (8)

1 (7)

0 (0)

0 (0)

2

26 (61)

6 (22)

6 (40)

3 (50)

3 (17)

3

1 (2)

19 (70)

8 (53)

3 (50)

15 (83)

T

n.s.

1

28 (65)

13 (48)

8 (53)

3 (50)

6 (33)

2

15 (35)

14 (52)

7 (47)

3 (50)

12 (67)

N

n.s.

0

27 (63)

13 (48)

8 (53)

4 (67)

14 (78)

1

16 (37)

14 (52)

7 (47)

2 (33)

4 (22)

% positive cells by immunohistochemistry

measured by digital image analysis (mean ± SD)*

ER

80 ± 13

62 ± 33

52 ± 26

2 ± 1

4 ± 7

< 0.0001

PR

53 ± 31

38 ± 36

19 ± 29

2 ± 2

3 ± 4

< 0.0001

AR

47 ± 20

32 ± 23

28 ± 21

33 ± 15

10 ± 15

< 0.0001

BCL2

56 ± 11

46 ± 24

33 ± 27

7 ± 6

18 ± 15

< 0.0001

HER2

7 ± 11

7 ± 12

37 ± 25

64 ± 19

1 ± 3

< 0.0001

Ki67

14 ± 7

40 ± 17

22 ± 12

31 ± 15

53 ± 16

< 0.0001

p53

13 ± 16

34 ± 32

19 ± 18

17 ± 26

44 ± 35

n.s.

p16

14 ± 8

14 ± 12

14 ± 7

10 ± 4

40 ± 21

< 0.0001

HIF-1α

9 ± 6

12 ± 10

12 ± 10

18 ± 13

18 ± 10

< 0.005

SATB1

12 ± 7

14 ± 10

13 ± 10

10 ± 4

19 ± 18

n.s.


* Statistical significance of variation between the groups tested by one-way ANOVA (logarithm-transformed values of HER2, Ki67, p53, p16, HIF-1α, SATB1 were used for the analysis, however, original values are presented in the table)

Laurinavicius et al. Diagnostic Pathology 2012 7:27   doi:10.1186/1746-1596-7-27

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