Table 1 |
||||||||||
|
Clinical pathological findings in kidney transplant recipients |
||||||||||
|
Age, years |
Gender |
Kidney disease |
Transplant type |
Time, mos |
Sirolimus trough levels, mean(range), ng/ml |
Other immuno-suppressants |
Clinical radiological presentation |
Biopsy type |
Pathological findings |
|
|
|
||||||||||
|
1* |
49 |
M** |
DM1 |
K/Cad |
11 |
11.7(6.2-18.7) |
C/P |
Bilateral mass-like consolidations |
EB |
ND |
|
|
||||||||||
|
2 |
25 |
F |
DM1 |
K/Cad |
20 |
C/MY/D |
Patchy bilateral consolidations |
EB |
BCLPD |
|
|
|
||||||||||
|
3 |
71 |
M |
PCKD |
K/Cad |
36 |
C/D |
Mediastinal lymphadenopathy |
EB LNB |
DLBCL |
|
|
|
||||||||||
|
4 |
58 |
F |
DM2 |
K/Cad |
5 |
8.8(4.0-17.1) |
C/P |
Respiratory failure Diffuse ground glass opacities |
EB THB |
Hemorrhage |
|
|
||||||||||
|
5 |
47 |
F |
HTN |
K/Cad |
210 |
C/MY/P |
Respiratory failure, loculated pneumonia |
EB |
Necrosis Fibrin |
|
|
|
||||||||||
|
6 |
72 |
M |
DM2 |
K/Cad |
20 |
4.8(2.0-8.2) |
C/P |
Spiculated lung lesion |
NB |
SQC |
|
|
||||||||||
|
7 |
77 |
M |
K/Cad |
116 |
C/D |
Pulmonary nodule |
EB |
SQC |
||
|
|
||||||||||
|
8 |
71 |
M |
pANCA |
K/Cad |
10 |
15.1 |
C/P |
Right lower lobe mass |
EB |
ND |
|
|
||||||||||
|
Diffuse ground glass opacities |
||||||||||
|
|
||||||||||
|
9 |
48 |
F |
NA |
K/Cad |
32 |
NA |
MY/P |
Left lower lobe nodule |
EB |
Necrosis Fibrin |
|
|
||||||||||
|
10 |
39 |
M |
GN |
K/Cad |
80 |
10.2(8.1-11.8) |
C/P |
Respiratory failure, diffuse ground glass opacities with crazy paving pattern |
THB EB |
Hemorrhage PAP OP |
|
|
||||||||||
|
11 |
45 |
F |
NA |
K/Cad, LR |
345 |
C/P |
Collapsed lung, pneumonia |
EB |
OP |
|
|
|
||||||||||
|
12 |
58 |
F |
HTN |
K/Cad |
24 |
19.7 |
C/P |
Respiratory failure, diffuse ground glass opacities |
EB THB |
Hemorrhage |
|
|
||||||||||
|
13 |
44 |
F |
DM2 |
K/LR |
36 |
5.3(3.2-6.9) |
C/P |
Mediastinal lymphadenopathy, patchy ground glass opacities |
EB |
ND |
|
|
||||||||||
|
14 |
46 |
M |
WG |
K/LR |
175 |
C/MY/P |
Diffuse ground glass opacities, lung nodules |
EB NB |
Hemorrhage Capillaritis |
|
|
|
||||||||||
|
15 |
49 |
F |
DM |
K |
73 |
8.1(4.3-11.6) |
C/P |
Bilateral ground glass opacification with right lower lobe consolidation |
EB |
OP |
|
|
||||||||||
|
16 |
34 |
F |
DM1 |
KP/Cad |
19 |
4.2(2.4-6.7) |
C/P |
Respiratory failure, diffuse ground glass opacities |
THB |
DAD Hemorrhage |
|
|
||||||||||
|
17 |
43 |
M |
DM1 |
KP |
41 |
4.4 |
C/P |
Nodular right lower lobe infiltrate |
EB |
ND |
|
|
||||||||||
|
18 |
69 |
M |
DM2 |
K/LU |
4 |
11.0(5.0-14.9) |
C/P |
Bilateral lung nodules and mediastinal lymphadenopathy |
NB |
BCLPD |
|
|
||||||||||
|
19 |
71 |
M |
IgA |
K/LR |
114 |
C/P |
Dyspnea, diffuse ground glass opacities |
EB |
PAP |
|
|
|
||||||||||
|
20 |
60 |
M |
GN |
K/LR |
89 |
C/MY/D |
Lung nodule |
EB |
ND |
|
|
|
||||||||||
|
21 |
65 |
M |
K/LR |
41 |
6.8(2.8-12.0) |
MA/P |
Bilateral hypermetabolic lung nodules |
THB |
PJ granulomas |
|
|
|
||||||||||
|
22 |
60 |
M |
GN |
K/LR |
66 |
C/P |
Lung mass |
THB |
ADC |
|
|
|
||||||||||
|
23 |
52 |
M |
DM1 |
KP/Cad |
73 |
C/P |
Lung mass |
EB |
SQC |
|
|
|
||||||||||
|
24 |
34 |
M |
GN |
K/Cad |
38 |
10.2(6.1-14.3) |
C/P |
Bilateral ground glass opacities Loculated right sided pleural effusion |
EB |
Fibrin Necrosis |
|
|
||||||||||
|
25 |
36 |
F |
NA |
K |
180 |
C/P |
Bilateral lung nodules, lymphadenopathy |
THB NB |
LYG |
|
|
|
||||||||||
|
26 |
62 |
M |
IN |
K/LR |
115 |
C/P |
Lung mass |
NB |
ADC |
|
|
|
||||||||||
|
27 |
53 |
M |
PCKD |
K/LU |
61 |
2.0 |
MA/P |
Lung nodule, pleural effusion |
EB |
ND |
|
|
||||||||||
|
28 |
32 |
M |
CR |
K/LU |
220 |
8.6(4.4-13.2) |
C/MA/P |
Dyspnea, patchy ground glass opacities |
EB |
OP |
|
|
||||||||||
|
(*) - the cases are arranged in chronological order; (**)-M male; F female; DM diabetes mellitus; PCKD polycystic kidney disease; HTN hypertension; p-ANCA p-ANCA vasculitis; GN glomerulonephritis; WG Wegner's granulomatosis; IgA IgA nephropathy; IN interstitial nephritis; CR chronic reflux; K kidney transplant; KP kidney and pancreas transplant; Cad cadaveric kidney; LR living related kidney; LU living unrelated kidney; EB endobronchial biopsy; THB thoracoscopic biopsy; NB needle biopsy; LNB lymph node biopsy; C cyclosporine; P prednisone; D dexamethasone; MY mycophenolate mofetil; MA mycophenolic acid; ND not diagnostic; SQC squamous cell carcinoma; ADC adenocarcinoma; BCLPD B-cell lymphoproliferative disorder; DLBCL diffuse large B-cell lymphoma; LYG lymphomatoid granulomatosis; OP organizing pneumonia; DAD diffuse alveolar damage; PJ Pneumocystis jiroveci; PAP pulmonary alveolar proteinosis; NA not available |
||||||||||
|
Kirby et al. Diagnostic Pathology 2012 7:25 doi:10.1186/1746-1596-7-25 |
||||||||||
