Table 1

Reported cases of the urinary bladder PEComas in the English-Language Literature and their clinicopathologic features
Case Authors/Year/ Age(y) /Sex Symptoms Site/Size (cm) Border Nuclear grade and cellularity MF/ 50 HPF Necrosis Vascular invasion Immunohistochemistry Treatment Outcomes/follow-up (mo)
1 Pan 2003 [11] 33/F Symptomless Left lateral inferior /4.0 W U 0 No U HMB45 (+), SMA (+), vimentin (−), desmin (−),S-100 protein (−), Melan-A (−), pan-cytokeratin (KL-1) (−), ER (−), PR (−) Partial cystectomy ANEDx72
2 Kalyanasundaram 2005 [12] 19/F Hematuria Left lateral /3.0 I High Few U U HMB45 (+), cytokeratin (−), S-100 (−), synaptophysin (−), vimentin (−), desmin (−), chromogranin A (−) TURBT U
3 Parfitt 2006 [13] 48/M Lower abdominal pain and dysuria Posterior mid-wall /3.0 I High 0 Inconspicuous U HMB45 (+), Melan-A (+), SMA (+), desmin (+), c-kit (+), S-100 protein (−), pan-cytokeratin (AE1/AE3) (−), vimentin (−), MSA (−), myoglobin (−), CD31 (−), CD34 (−), WT-1 (−) Partial cystectomy and partial small bowel resection with adjuvant INF-a immunotherapy ANEDx48
4 Weinreb 2007 [14] 39/M U Dome/urachal remnant cyst /5.0 I, focally High, focal Isolated Yes, focal No HMB45 (+), SMA (+), MSA (+), desmin (+), Melan-A (+), S-100 protein (+), MiTF (+), cyclin D1 (+) Partial cystectomy ANEDx8
5 Pianezza 2008 [15] 24/F Chronic pelvic pain Posterior/3.4 I, focally Low to moderate 1 No U HMB45 (+), S-100 protein (+), H-caldesmon (+), actin (+), Melan-A (−), CD34 (−), A103 (−), pankeratin (−), calretinin (−), CD99 (−), ALK-1 (−), c-kit (−), desmin (−) Partial cystectomy ANEDx3
6 Sukov 2009 [16] 36/M Hematuria Anterior /4.8 I Low to moderate 0 Yes, focal U HMB45 (+), SMA (+), tyrosinase (+), desmin (−), Melan-A (−) Partial cystectomy ANEDx10
7 37/M Hematuria Dome /U W Low to moderate 0 No U HMB45 (+), pan-cytokeratin (−), vimentin (−), CD56 (−), chromogranin A (−), Melan-A (−), S-100 protein (−), synaptophysin (−), SMA (−), high-molecular-weight cytokeratin (−), inhibin (−) TURBT ANEDx21
8 26/F U Anterior /5.0 W Low 0 Yes (related to embolization) U HMB45 (+), SMA (+), vimentin (+), Melan-A (−), tyrosinase (+), S-100 protein (−), c-kit (−), MSA (−), cytokeratin (−) Embolization and partial cystectomy U
9 Huang 2011 [17] 23/M Frequent micturition and odynuria Left lateral /9.2 W Low 0 U U HMB45 (+), vimentin (+), SMA (+), S-100 protein (−), Melan-A (−), synaptophysin (−), c-kit (−), CD34 (−), chromogranin A (−), cytokeratin 8 (−) Tumorectomy and partial cystectomy U
10 Chan 2011 [18] 42/M Vague urethral pain Right lateral /6.0 W Low to moderate? <1 No U HMB45 (+), S-100 protein (+), MiTF (+), SMA (+), calponin (+), vimentin (+), desmin (−), myogenin (−),TFE3 (−), pan-cytokeratin (AE1/AE3) (−), CD34 (−), ALK-1 (−), synaptophysin (−), c-kit (−), Ki67 (+, 1%) TURBT and then partial cystectomy U
11 Kyrou 2012 [19] 44/F Dysmenorrhea Left posterior /2.7 U U 0 No U HMB45(+), S-100 protein (+), EMA (−), cytokeratin (−), desmin(−) Partial colpectomy and cystectomy/ right ovariectomy/ pelvic lymphadenectomy ANEDx30
12 Shringarpure 2012 [20] 39/M Painless hematuria Left vesicoureteric junction/3 U U U U U HMB45 (+), Melan-A (+), SMA (+), vimentin (+), MSA (+), S-100 protein (+), cytokeratin (−), desmin(−) TURBT ANEDx3
13 Present case 16/F Abdominal discomfort and micturition Posterior/2.5 W Low 0 No No HMB45 (+), SMA (+), MSA (+), desmin (−), H-caldesmon (+), Melan-A (−), ALK-1 (−), myogenin (−), EMA (−), pan-cytokeratin (AE1/AE3) (−), S-100 protein (−), Ki-67 (+, 2%) TURBT ANEDx13

W indicates well-circumscribed; I, infiltrative; MF, mitotic figures; TURBT, transurethral resection of bladder tumor; ANED, alive, not evidence of disease; U, unknown.

Yin et al.

Yin et al. Diagnostic Pathology 2012 7:183   doi:10.1186/1746-1596-7-183

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