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Open Access Research

The ectopic expression of BRCA1 is associated with genesis, progression, and prognosis of breast cancer in young patients

Qingli Zhang*, Qinghui Zhang, Hua Cong and Xiaoli Zhang

Author affiliations

School of Medicine, Shandong University, Jinan, 250012, P.R. China

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Citation and License

Diagnostic Pathology 2012, 7:181  doi:10.1186/1746-1596-7-181

Published: 31 December 2012

Abstract

Objective

The study is to explore the histopathological features and the molecular marker expression of young women with breast cancers.

Methods

The pathological data of 367 cases of female breast cancer patients were retrospectively analyzed, focusing on the analysis of young breast cancer incidence trends and the clinical and pathological features.

Results

Compared with elderly breast cancer patients, young women with breast cancers had larger tumor sizes, higher histological grades, and lymph node metastasis rates. The majority of patients were in the PTNM III stage, with the clinical and pathological features of strong invasiveness. The positive expression rate of the BRCA1 protein in the young group was higher than that in the old group. BRCA1 expression was positively correlated with the PTNM stage and axillary lymph node metastasis (P < 0.05).

Conclusions

The ectopic expression of BRCA1 is associated with the genesis, progression, and prognosis of young breast cancer patients.

Virtual slides

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1628000054838044 webcite

Keywords:
BRCA1; WWOX; Gene detection