Table 2

Association of LMP1 and LMP2A expression with clinical characteristics and selected biological markers of ENKTL
Groups No. LMP1 expression p value LMP2A expression p value
Positive Negative Positive Negative
Gender
 Male 13 7 6 0.687 4 9 0.029*
 Female 3 2 1 3 0
Age (years)
 ≤40 y 5 3 2 0.838 3 2 0.377
 >40 y 11 6 5 4 7
Ann Arbor Stage
 I-II 14 7 7 0.182 6 8 0.849
 III-IV 2 2 0 1 1
LDH level
 High 5 3 2 0.838 2 3 0.838
 Normal 11 6 5 5 6
B symptoms
 Positive 8 7 1 0.012* 4 4 0.614
 Negative 8 2 6 3 5
IPI
 Low/Low-intermediate 11 5 6 0.197 4 7 0.377
 High-intermediate/High 5 4 1 3 2
Response to treatment
 Complete remission 7 4 3 0.493 4 3 0.319
 Partial remission 8 5 3 2 6
 No response 1 0 1 1 0
Prognosis
 Live 7 2 5 0.049* 1 6 0.036*
 Dead 9 7 2 6 3

LDH: lactate dehydrogenase; IPI: international prognostic index; LMP1: latent membrane protein 1; LMP2A: latent membrane protein 2A; * P < 0.05.

Mao et al.

Mao et al. Diagnostic Pathology 2012 7:178   doi:10.1186/1746-1596-7-178

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