Table 1

Clinical and histologic features of 16 patients with ENKTL
Patient no. Age Sex Primary sites Ann Arbor stage LDH level B symptoms IPI Therapy Response to treatment LMP1 expression (IHS) LMP2A expression (IHS)
1 36 M Nasal cavity II Normal Positive LI CHOP + FLAG PR 6 6
2 36 M Oropharynx III High Positive HI CHOP PR 4 2
3 57 M Nasal cavity II Normal Negative HI Surgery + CHOP CR 2 1
4 55 M Larynx I Normal Positive LI Surgery + CHOP PR 8 1
5 49 F Nasal cavity II High Negative L Surgery NR 1 4
6 51 M Nasal cavity I High Negative LI CHOP + Radiotherapy PR 2 1
7 67 M Nasal cavity II Normal Positive HI CHOP + GDP + CVAD CR 9 4
8 25 M Oropharynx, palate II Normal Negative L CHOPE + ICE + Radiotherapy CR 1 9
9 71 M Nasal cavity I High Positive LI CHOP + SMILE CR 4 2
10 36 M Nasal cavity II Normal Negative L CHOP PR 6 1
11 63 M Nasal cavity I Normal Negative L CEVP + Radiotherapy PR 2 1
12 56 M Nasal cavity II Normal Positive LI Surgery + CHOP PR 3 2
13 66 F Larynx II High Positive HI Surgery CR 6 8
14 47 M Nasopharynx I Normal Negative L VEPA + Radiotherapy CR 8 1
15 51 F Nasal cavity III Normal Positive HI DICE + SMILE PR 9 9
16 27 M Nasal cavity II Normal Negative LI Surgery + CHOP CR 3 6

LDH: lactate dehydrogenase; IPI: international prognostic index; IHS: immunohistochemistry score; LMP1: latent membrane protein 1; LMP2A: latent membrane protein 2A; L: low risk; LI: low-intermiediate risk; HI: high-intermiediate risk; CR: complete remission; PR: partial remission; NR: no response; CHOP: cyclophosphamide, hydroxydaunomycin, oncovin, prednisone; FLAG: fludarabine, arabinosylcytosine, granulocyte colony-stimulating factor; GDP: gemcitabine, dexamethasone, cisplatin; CVAD: cyclophosphamide, vindesine sulfate, adriamycin, cisplatin; CHOPE: cyclophosphamide, hydroxydaunomycin, oncovin, prednisone, etoposide; ICE: ifosfamide, cisplatin, etoposide; SMILE: steroid, methotrexate, ifosfamide, l-asparaginase, etoposide; CEVP: cyclophosphamide, epirubicin, vincristine, prednisone; VEPA: vincristine, cyclophosphamide, doxorubicin, predonisolone; DICE: dexamethasone, ifosfamide, cisplatin, etoposide.

Mao et al.

Mao et al. Diagnostic Pathology 2012 7:178   doi:10.1186/1746-1596-7-178

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