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Open Access Research

LMP1 and LMP2A are potential prognostic markers of extranodal NK/T-cell lymphoma, nasal type (ENKTL)

Yuan Mao1, Da-Wei Zhang2, Huijun Zhu3, Hong Lin4, Lin Xiong5, Qing Cao2, Ying Liu1, Qing-Dong Li1, Jia-Ren Xu6*, Lin-Feng Xu7* and Ren-Jie Chen2*

Author affiliations

1 Department of Otolaryngology-Head and Neck Surgery, Jiangsu Provincial Hospital, No.65 Jiangsu Road, Nanjing, 210029, China

2 Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Nanjing Medical University, No.121 Jiang jia yuan, Nanjing 210011, China

3 Department of Pathology, Affiliated Hospital of Nantong University, No.20 Xisi Road, Nantong, 226001, China

4 Jiangsu Provincial Blood Center, No.179 Longpan Road, Nanjing, 210042, China

5 Department of Pathology, The Second Affiliated Hospital of Nanjing Medical University, No.121 Jiang jia yuan, Nanjing, 210011, China

6 Department of Hematology and Oncology, Jiangsu Provincial Hospital, No.65 Jiangsu Road, Nanjing 210029, China

7 Department of General Surgery, The Second Affiliated Hospital of Nanjing Medical University, No.121 Jiang jia yuan, Nanjing 210011, China

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Citation and License

Diagnostic Pathology 2012, 7:178  doi:10.1186/1746-1596-7-178

Published: 13 December 2012

Abstract

Background

Latent membrane protein (LMP) 1 and LMP2A encoded by Epstein-Barr virus (EBV) are associated with the development of malignancies, but their expression in extranodal NK/T-cell lymphoma, nasal type (ENKTL) and the relationship with clinical characteristics of this disease remain poorly understood. In the present study, we examined the expression of LMP1 and LMP2A in ENKTL, and investigated the correlations between LMP1 and LMP2A expression with clinicopathological characteristics of ENKTL patients.

Methods

Paraffin sections of surgically removed samples from 16 ENKTL patients were analyzed by immunohistochemistry and the related clinicopathological data were collected and analyzed.

Results

Elevated expression (immunohistochemistry score ≥ 4) of LMP1 and LMP2A was detected in the tumor cells of ENKTL. High LMP1 expression was associated with positive B symptoms (p = 0.012), while high LMP2A expression was related to gender (p = 0.029). The expression of both LMP1 and LMP2A showed significant correlations with patients’ overall survival (p = 0.049, p = 0.036).

Conclusion

LMP1 and LMP2A may be prognostic indicators of survival in patients with ENKTL.

Virtual slides

http://www.diagnosticpathology.diagnomx.eu/vs/2443352538545899 webcite

Keywords:
LMP1; LMP2A; EBV; ENKTL; Prognosis; Tumor marker