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Prostatic stromal sarcoma with neuroectodermal differentiation

Hitoshi Yamazaki1*, Teppei Ohyama2, Toshiki Tsuboi2, Yoshinori Taoka2, Dai Kohguchi2, Hiroyoshi Iguchi3 and Teruaki Ao2

Author Affiliations

1 Department of Pathology, Medical center hospital, Kitasato Institute, Kitasato University, Saitama, Japan

2 Department of Urology, Medical center hospital, Kitasato Institute, Kitasato University, Saitama, Japan

3 Department of Radiology, Medical center hospital, Kitasato Institute, Kitasato University, Saitama, Japan

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Diagnostic Pathology 2012, 7:173  doi:10.1186/1746-1596-7-173

Published: 7 December 2012


Prostatic stromal sarcoma is a fairly rare tumor that constitutes approximately 0.1–0.2% of all prostatic cancers. Detailed characteristics of the tumor are still unclear due to its rarity.

We describe a case of prostatic stromal sarcoma in a 63 year-old man who suffered from urinary obstructive symptoms. Palliative transuterine resection was performed and the preliminary histopathological diagnosis was neuroendocrine carcinoma. After chemotherapy, total pelvic exenteration was performed. Histopathologically, the tumor was composed of monotonously proliferating small to medium-sized round cells, which existed in compact islands with loose or dense fibrovascular networks. Immunohistochemically, the tumor cells were widely positive for vimentin, CD56, CD99 and focally positive for synaptophysin, CD10, progesterone receptor, desmin and CD34, but negative for EMA, cytokeratin, estrogen receptor, S-100 and myoglobin. Most of the previously reported tumors exhibited positive stainability for CD10 and progesterone receptor. In addition to these markers, expressions of CD56, CD99 and synaptophysin were characteristically detected in our case. To the best of our knowledge, we present the first case of prostatic stromal sarcoma with characteristic immunohistochemical staining properties. Although the biological characteristics of this rare tumor have not yet been elucidated, these findings suggest prostatic stromal sarcoma can potentially show neuroectodermal differentiation.

The virtual slide(s) for this article can be found here: webcite

Prostatic stromal sarcoma; STUMP; Immunohistochemistry; CD99; CD56; Synaptophysin; Neuroectodermal differentiation