Table 1

The main characteristics of these studies and the distribution of MTHFR Ala222Val genotypes and alleles among cases and controls
First author [Inference] Year Ethnicity Cases Controls HWE
CC CT TT CC CT TT
Sharp [8] 2002 Caucasian 30 19 5 25 21 11 0.103
Campbell [9] 2002 Caucasian 140 162 33 118 92 23 0.420
Semenza [10] 2003 Caucasian 42 58 5 112 111 24 0.643
Langsenlehner [11] 2003 Caucasian 208 222 64 215 215 65 0.333
Ergul [12] 2003 Caucasian 60 41 17 94 87 12 0.164
Shrubsole [13] 2004 Asian 374 555 183 387 577 196 0.442
Fo¨rsti [14] 2004 Caucasian 134 81 8 181 104 13 0.689
Lee [15] 2004 Asian 58 96 32 50 80 17 0.076
Grieu [16] 2004 Caucasian 166 141 27 242 259 50 0.100
Lin [17] 2004 Asian 43 38 7 173 145 24 0.389
Qi [18] 2004 Asian 42 104 71 59 105 54 0.593
Chen [19] 2005 Mixed 398 476 189 440 509 155 0.689
Kalemi [20] 2005 Caucasian 19 16 7 23 20 8 0.313
Deligezer [21] 2005 Caucasian 98 68 23 128 83 12 0.759
Justenhoven [22] 2005 Caucasian 249 247 61 261 279 93 0.193
Chou [23] 2006 Asian 73 51 18 132 120 33 0.475
Kalyankumar [24] 2006 Caucasian 45 37 6 61 31 3 0.693
Xu [25] 2007 Mixed 398 476 189 440 509 155 0.689
Hekim [26] 2007 Caucasian 22 16 2 38 26 4 0.872
Macis [27] 2007 Caucasian 14 20 12 28 41 11 0.511
Yu [28] 2007 Asian 56 54 9 225 170 25 0.336
Reljic [29] 2007 Caucasian 40 44 9 27 34 4 0.114
Inoue [30] 2008 Asian 239 120 21 393 226 43 0.178
Kotsopoulos [31] 2008 Caucasian 383 421 140 252 341 87 0.087
Suzuki [32] 2008 Asian 150 220 84 338 425 146 0.522
Cheng [33] 2008 Asian 185 133 31 268 221 41 0.624
Langsenlehner [34] 2008 Caucasian 51 43 11 40 48 17 0.685
Ericson [35] 2009 Caucasian 255 235 50 531 452 91 0.707
Gao [36] 2009 Asian 202 305 117 235 301 88 0.592
Ma [37] 2009 Asian 124 183 81 115 188 84 0.663
Platek [38] 2009 Mixed 429 446 119 788 795 219 0.398
Henrı′quez-Herna′ndez [39] 2009 Caucasian 52 65 18 107 138 47 0.823
Cam [40] 2009 Caucasian 48 49 13 47 42 6 0.398
Maruti [41] 2009 Mixed 133 139 46 301 284 62 0.672
Ma [42] 2009 Mixed 225 188 45 222 187 49 0.309
Li [43] 2009 Asian 38 17 10 90 50 3 0.187
Yuan [44] 2009 Asian 16 35 29 32 35 13 0.516
Jin [45] 2009 Asian 18 20 3 49 41 10 0.742
Bentley [46] 2010 Caucasian 346 402 191 429 529 205 0.060
Alshatwi [47] 2010 Asian 34 50 16 36 49 15 0.800
Sangrajrang [48] 2010 Asian 410 144 9 366 110 11 0.427
Weiner [49] 2010 Caucasian 399 364 74 386 326 66 0.808
Prasad [50] 2011 Asian 124 5 1 116 8 1 0.062
Batschauer [51] 2011 Caucasian 27 34 7 42 34 9 0.593
Mohammad [52] 2011 Asian 168 53 1 198 37 0 0.190
Naushad [53] 2011 Asian 185 56 3 205 39 0 0.175
Cerne [54] 2011 Caucasian 222 238 62 108 124 37 0.882
Akram [55] 2012 Caucasian 65 25 20 55 45 10 0.855
Barbosa [56] 2012 Mixed 76 83 17 87 70 19 0.389
Lajin [57] 2012 Caucasian 44 52 23 65 48 13 0.359
Jakubowska [58] 2012 Mixed 2032 2166 580 1447 1481 422 0.156

HWE Hardy–Weinberg equilibrium.

Yu and Chen

Yu and Chen Diagnostic Pathology 2012 7:171   doi:10.1186/1746-1596-7-171

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