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Open Access Case Report

Successful treatment of gallbladder mixed adenoneuroendocrine carcinoma with neo-adjuvant chemotherapy

Wu Song1, Wenfang Chen2, Sheng Zhang1, Jianjun Peng1 and Yulong He1*

Author Affiliations

1 Department of Surgery, the First Affiliated Hospital, Sun Yat-sen University, 58# Zhongshan Road 2, Guangzhou 510080, China

2 Department of Pathology, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou China

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Diagnostic Pathology 2012, 7:163  doi:10.1186/1746-1596-7-163

Published: 27 November 2012

Abstract

Mixed adenoneuroendocrine carcinoma (MANEC) carcinomas rarely occur in the gallbladder. Here we reported a case of giant gallbladder unresectable mass with local liver invasion and omentum metastasis, which proved to be neuroendocrine carcinoma (NEC) by biopsy, received successful radical operation after neo-adjuvant chemotherapy plus somatostatin treatment. The patient showed good response as the neoplasm diminished dramatically and showed clear margin after 6 courses of treatment. A radical operation including cholecystectomy, hepatic wedge resection of the gallbladder fossa segment and lymph node of group 8a and 8p resection was performed successfully. Postoperative histopathological examination revealed neuroendocrine carcinoma mixed with adenocarcinoma in the gallbladder wall. Followed up showed no evidence of recurrence after 7 months of the operation. We suggest that neo-adjuvant chemotherapy may be beneficial to gallbladder mixed neuroendocrine carcinomas in an advanced stage which could also be advantageous to NEC of other organs.

Virtual slides

http://www.diagnosticpathology.diagnomx.eu/vs/2731892837743787 webcite

Keywords:
Gallbladder; Neuroendocrine tumors; Neo-adjuvant chemotherapy; Mixed adenoneuroendocrine carcinoma