Table 3
Univariate analysis of pathological variables and two automated techniques (CD3+ cell counts from TMA and LQLI) for disease-free survival
Clinical & pathological variables No. % 3-yr DFS 5-yr DFS HR 95% CI P
TNM stage 2.97 1.29-6.81 0.009
II 78 67 91 87
III 39 33 74 67
Metastatic LNR ratio 4.49 1.81-11.13 <0.001
≤0.2 102 87 89 85
>0.2 15 13 58 58
Vascular embolism 4.05 1.75-9.37 0.001
Yes 41 35 73 66
No 76 65 92 89
Perineural invasion 2.96 1.28-6.85 0.01
Yes 25 21 67 60
No 92 79 90 86
MSI status 1.36 0.89-2.34 0.11
MSI - 107 91 84 80
MSI + 10 9 No event No event
Lymphocyte density (CD3+ cells/mm²) with TMA 2.54 1.1-6.4 0.04
High [CD3+] 50 43 92 90
Low [CD3+] 67 57 80 74
CD3+ LQLI pattern 4.75 2.33-9.68 <0.0001
Pattern 1 24 20 96 96
Pattern 2 71 61 90 86
Pattern 3 22 19 59 45
CD45R0+ LQLI pattern
Pattern 1 23 19 96 96 3.85 1.09-7.77 <0.001
Pattern 2 70 60 90 85
Pattern 3 24 21 62 44

LNR lymph node ratio, HR hazard ratio, CI confidence interval, DFS disease-free survival.

Allard et al. Diagnostic Pathology 2012 7:156   doi:10.1186/1746-1596-7-156

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