Figure 3.

a: Primary bladder adenocarcinoma demonstrating apical brush border staining with villin. Very similar staining pattern was also seen in metastatic colorectal adenocarcinoma. (DAB chromogen, x100). b: Primary bladder adenocarcinoma demonstrating strong diffuse nuclear staining with CDX-2. Metastatic colorectal adenocarcinoma demonstrated same staining pattern. (DAB chromogen, x100). c: Primary bladder adenocarcinoma shows strong cytoplasmic staining with CK7. Overall, it was infrequently seen in glandular bladder tumors, however slightly more frequently in primary than metastatic adenocarcinomas. (DAB chromogen, x100). d: Primary bladder adenocarcinoma shows diffuse strong cytoplasmic positivity for CK20. This was also seen in majority of metastatic colorectal adenocarcinoma. (DAB chromogen, x100).