a: Primary bladder adenocarcinoma. Strong cytoplasmic membranous staining with β-catenin (DAB chromogen, x100). b: Metastatic colorectal adenocarcinoma. Strong nuclear staining in addition to cytoplasmic staining with β-catenin (DAB chromogen, x100). c: Primary bladder adenocarcinoma. Strong nuclear staining with e-cadherin in addition to weaker cytoplasmic staining pattern. This pattern was more frequent in this group of tumor in contrast to metastatic colorectal adenocarcinoma (DAB chromogen x200). d: Metastatic colorectal adenocarcinoma. Prominent cytoplasmic membranous staining with e-cadherin. Note the absence of nuclear staining (DAB chromogen, x200).
Roy et al. Diagnostic Pathology 2012 7:151 doi:10.1186/1746-1596-7-151