Table 2

Morphologic features of the tumors and correlation with BLBCs
Total (n=500) BLBC (n=47) NBBC (n=453) p value Odds ratio (95% CI)
Mitotic number Mean: 11.5±9 Mean: 25±9 Mean: 10±8 p<0.0001 1.17 (1.12-1.21)
Median: 9 Median: 24 Median: 8
Range: 1-60 Range: 8-60 Range: 1-48
0-7 219 (43.8%) 0 (0%) 219 (48.3%)
8-14 131 (26.2%) 3 (6.4%) 128 (28.3%)
≥15 150 (30%) 44 (93.6%) 106 (23.4%)
Tubule formation p<0.0001 13.38 (4.31-44.69)
1 36 (7.2%) 0 (0%) 36 (8%)
2 203 (40.6%) 3 (6.4%) 200 (44.1%)
3 261 (52.2%) 44 (93.6%) 217 (47.9%)
Nuclear grade p<0.0001 42.80 (5.92-309.27)
1 54 (10.8%) 0 (0%) 54 (11.9%)
2 192 (38.4%) 1 (2.1%) 191 (42.2%)
3 254 (50.8%) 46 (97.9%) 208 (45.9%)
Central scar p=0.68
Present 157 (31.4%) 16 (34%) 141 (31.1%)
Absent 343 (68.6%) 31 (66%) 312 (68.9%)
Central necrosis p<0.0001 10.08 (5.24-19.38)
Present 104 (20.8%) 31 (66%) 73 (16.1%)
Absent 396 (79.2%) 16 (34%) 380 (83.9%)
Geographic necrosis p<0.0001 5.23 (2.73-10.02)
Present 71 (14.2%) 19 (40.4%) 52 (11.5%)
Absent 429 (85.8%) 28 (59.6%) 401 (88.5%)
CIS p<0.0001 5.29 (2.84-9.86)
Present 382 (76.2%) 20 (42.6%) 361 (79.7%)
Absent 119 (23.8%) 27 (57.4%) 92 (20.3%)
Stromal lymphocytic response p<0.0001 27.02 (8.71-83.92)
None 174 (34.8%) 4 (8.5%) 170 (37.5%)
Mild 158 (31.6%) 4 (8.5%) 154 (34%)
Moderate 114 (22.8%) 18 (38.3%) 96 (21.2%)
Marked 54 (10.8%) 21 (44.7%) 33 (7.3%)
Tumor growth p<0.0001 7.14 (3.80-13.42)
Pushing 99 (20%) 27 (57.5%) 72 (15.9%)
Infiltrative 401 (80%) 20 (42.6%) 381 (84.1%)
Prominent nucleol p<0.0001 10.36 (4.31-24.91)
Present 221 (44.2%) 41 (87.2%) 180 (39.7%)
Absent 279 (55.8%) 6 (12.8%) 273 (60.3%)
Vesicular chromatin p<0.0001 15.59 (6.47-37.59)
Present 179 (35.8%) 41 (87.2%) 138 (30.5%)
Absent 321 (64.2%) 6 (12.8%) 315 (69.5%)
Amount of cytoplasm p=0.27
Scant 191 (38.2%) 15 (31.9%) 176 (38.8%)
Moderate 132 (26.4%) 15 (31.9%) 162 (35.8%)
Copicious 177 (35.4%) 17 (36.2%) 115 (25.4%)

Cakir et al.

Cakir et al. Diagnostic Pathology 2012 7:145   doi:10.1186/1746-1596-7-145

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