The morphology of liver tissue from patients with HBV-related acute-on-chronic liver failure (HBV-ACLF). (A) HE staining demonstrated that liver tissue sections from HBV-ACLF patients have severe necrosis, hepatocytes with ballooning degeneration and collapse of the parenchyma; immunohistochemistry showed that (B) the expression of HBsAg was found in hepatocytes of HBV-ACLF patients and that a cohort of (C) CD68+ macrophages, (D) CD3+ T cells, and (E) CD16+ monocytes and (F) fibrinogen+ cells were infiltrated and distributed throughout the livers of HBV-ACLF patients. The arrows indicate positive cells, and the scale bar indicates 20 μm.
Xu et al. Diagnostic Pathology 2012 7:142 doi:10.1186/1746-1596-7-142