Table 2

Meta-analysis of the COMT Val158Met polymorphism on BC susceptibility
Comparison Population Sample size No. of studies Test of association Mode Test of heterogeneity
Case Control OR 95% CI P value χ2 P value I2
LL vs. HH Overall 17,223 23,069 54 0.999 0.925-1.078 0.976 R 117.76 0.000 55.0
Caucasian 12,942 18,066 32 0.960 0.897-1.028 0.240 R 49.28 0.020 37.1
Asian 3,009 3,790 17 1.243 0.942-1.641 0.125 R 54.34 0.000 70.6
Pre- 2,095 2,523 21 1.049 0.825-1.334 0.697 R 48.22 0.000 58.5
Post- 7,215 10,138 26 0.982 0.875-1.102 0.757 R 45.40 0.008 44.9
PB 17,223 23,069 28 0.999 0.925-1.078 0.381 R 48.00 0.008 43.7
HB 3,800 6,169 20 1.151 0.946-1.402 0.160 R 58.86 0.000 67.7
FB 1,351 1,140 5 0.848 0.712-1.010 0.064 F 4.43 0.351 9.7
HL vs. HH Overall 22,589 33,568 54 1.005 0.959-1.052 0.845 R 72.70 0.038 27.1
Caucasian 19,059 25,912 32 0.999 0.958-1.042 0.968 F 30.14 0.510 0.0
Asian 4,525 5,781 17 1.052 0.923-1.200 0.448 R 36.85 0.002 56.6
Pre- 3,204 3,877 21 0.962 0.871-1.062 0.440 F 27.59 0.119 27.5
Post- 10,480 14,476 26 1.009 0.954-1.067 0.762 F 33.83 0.112 26.1
PB 17,648 22,679 28 0.987 0.945-1.030 0.547 F 3.60 0.463 0.0
HB 5,751 9,128 20 1.075 0.966-1.195 0.187 R 33.89 0.019 43.9
FB 2,102 1,674 5 0.950 0.824-1.094 0.476 F 30.98 0.272 12.9
LL vs. HL Overall 23,594 31,759 54 0.983 0.926-1.045 0.586 R 95.26 0.000 44.4
Caucasian 19,579 27,208 32 0.954 0.911-1.001 0.055 F 36.02 0.245 13.9
Asian 2,538 3,135 17 1.170 0.895-1.528 0.251 R 49.83 0.000 67.9
Pre- 2,507 3,200 21 1.060 0.851-1.320 0.606 R 49.32 0.000 59.4
Post- 10,243 14,548 26 0.969 0.915-1.025 0.271 F 32.47 0.271 23.0
PB 16,437 21,768 28 0.969 0.909-1.032 0.324 R 39.76 0.054 32.1
HB 4,973 8,203 20 1.060 0.902-1.245 0.478 R 48.71 0.000 61.0
FB 2,099 1,714 5 0.882 0.769-1.012 0.073 F 4.37 0.358 8.6
LL vs. HL+HH Overall 34,358 45,429 56 0.988 0.929-1.050 0.702 R 108.88 0.000 51.3
Caucasian 25,790 35,593 32 0.956 0.909-1.006 0.081 R 43.54 0.067 28.8
Asian 5,770 7,552 17 1.204 0.927-1.564 0.164 R 52.91 0.000 69.8
Pre- 3,903 4.800 21 1.053 0.855-1.297 0.627 R 49.44 0.000 59.5
Post- 13,969 19,581 26 0.980 0.901-1.065 0.629 R 37.85 0.048 33.9
PB 24,205 31,307 30 0.966 0.906-1.030 0.290 R 45.36 0.015 40.5
HB 7,262 11,750 20 1.098 0.934-1.289 0.257 R 54.38 0.000 65.1
FB 2,776 2,264 5 0.877 0.760-1.013 0.074 F 4.62 0.328 13.5
LL+HL vs. HH Overall 34,358 45,429 56 1.001 0.954-1.051 0.953 R 93.20 0.001 41.0
Caucasian 25,790 35,593 32 0.982 0.944-1.022 0.369 F 37.71 0.189 17.8
Asian 5,770 7,552 17 1.072 0.952-1.208 0.253 R 42.65 0.001 60.1
Pre- 3,933 4.839 22 1.016 0.890-1.160 0.815 R 33.81 0.038 37.9
Post- 14,001 19,604 27 1.001 0.924-1.084 0.987 R 40.17 0.038 35.3
PB 24,205 31,307 30 0.975 0.924-1.028 0.343 R 42.89 0.047 32.4
HB 7,262 11,750 20 1.091 0.978-1.216 0.118 R 39.26 0.004 51.6
FB 2,776 2,264 5 0.914 0.799-1.044 0.186 F 3.81 0.432 0.0

OR odds ratio, CI confidence intervals, R random effects model, F fixed effects model, PB Population-based study, HB Hospital-based study, FB Familial-based study, Pre- Premenopausal, Post- Postmenopausal.

Qin et al.

Qin et al. Diagnostic Pathology 2012 7:136   doi:10.1186/1746-1596-7-136

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