Table 1
General characteristics of individual studies in the meta-analysis of COMT Val158Met polymorphism and breast cancer
Study, year Country Ethnicity No. of cases/controls BC diagnosis Matching criteria Genotyping method Menopausal status Control sources Quality control HWE6(p value)
Lavigne 1997 America Caucasian 113/114 NR Age, race PCR-RFLP Pre-, Post- HB NR 0.862
Thompson 1998 America Caucasian 281/289 Histologically confirmed Age, region PCR-RFLP Pre-, Post- PB NR 0.522
Millikana 1998 America Caucasian 389/379 Histologically confirmed Age, race PCR-RFLP Pre-, Post- PB Yes 0.916
Millikanb 1998 America Mixed/other 265/263 Histologically confirmed Age, race PCR-RFLP Pre-, Post- PB Yes 0.838
Huang 1999 China Asian 118/125 Pathologically conformed NR PCR-RFLP Pre-, Post- HB NR 0.612
Goodman 2001 America Caucasian 112/113 Histologically confirmed Age, race PCR-RFLP Mixed PB Yes 0.788
Mitrunen 2001 Finland Caucasian 481/480 Histologically confirmed NR PCR-RFLP Pre-, Post- PB NR 0.921
Yim 2001 Korea Asian 163/163 Histopathologically confirmed Age PCR-RFLP Pre-, Post- HB Yes 0.004
Jungestrom 2001 Sweden Caucasian 126/117 NR Age PCR-RFLP Pre- HB NR 0.209
Hamajima 2001 Japan Asian 150/165 Histologically confirmed NR PCR-RFLP Pre-, Post- HB NR 0.079
Kocabas 2002 Turkey Caucasian 84/103 Histologically confirmed Age PCR-RFLP Pre-, Post- HB NR 0.227
Comings 2003 America Caucasian 67/145 NR Region PCR-RFLP Post- PB NR 0.335
Wedren 2003 Sweden Caucasian 1490/1340 NR Age DASH Post- PB Yes 0.772
Wu 2003 America Asian 589/562 NR Age, race TaqMan Mixed PB NR 0.646
Tan 2003 China Asian 250/250 Histopathologically confirmed Age PCR-RFLP Pre-, Post- HB NR 0.174
Sazci 2004 Turkey Caucasian 130/224 Histopathologically confirmed Age PCR-RFLP Pre- PB NR 0.000
Dunning 2004 UK Caucasian 2850/1908 NR Age, region TaqMan Post- PB Yes 0.232
Hefler 2004 Austria Caucasian 391/1698 Histologically confirmed Age, region Sequencing Mixed HB Yes 0.577
Ahsan 2004 America Caucasian 313/262 Histopathologically confirmed Age LP Mixed FB Yes 0.108
Modugno 2005 America Caucasian 250/3950 Histopathologically confirmed NR TaqMan Post- PB NR 0.391
Lin 2005 China Asian 99/366 Pathologically conformed Age, region PCR-RFLP Mixed PB Yes 0.972
Lin 2005 China Asian 87/341 Pathologically conformed Age, region PCR-RFLP Mixed PB Yes 0.393
Marchand 2005 America Mixed/other 1339/1370 NR Age PCR-RFLP Post- PB NR 0.109
Wen 2005 China Asian 1120/1191 Pathologically conformed Age PCR-RFLP Pre-, post- PB Yes 0.698
Cheng 2005 China Asian 496/740 Pathologically conformed Age NR Mixed HB Yes 0.006
Gaudeta 2006 America Caucasian 1048/1092 Pathologically conformed Age MALDI-TOF Pre-, post- PB Yes 0.853
Gaudetb 2006 Poland Caucasian 1983/2279 Histopathologically confirmed Age TaqMan Mixed PB Yes 0.525
Gallicchio 2006 America Caucasian 81/1251 Pathologically conformed NR TaqMan Mixed PB NR 0.440
Chang 2006 China Asian 189/321 Histologically confirmed Age PCR-RFLP Mixed HB NR 0.068
Onay 2006 Canada Caucasian 398/372 Pathologically conformed Age TaqMan Pre- FB Yes 0.283
Pharoah 2007 UK Caucasian 2176/2012 NR NR TaqMan Mixed PB NR 0.287
Ralpha 2007 America Caucasian 1626/3286 NR Age TaqMan Pre-, post- HB Yes 0.758
Ralphb 2007 America Caucasian 500/1005 NR Age TaqMan Pre-, post- HB Yes 0.549
Akisik 2007 Turkey Caucasian 114/108 NR Age PCR-RFLP Mixed NR NR 0.966
Hu 2007 China Asian 112/110 Pathologically conformed Age Sequencing Pre-, post- HB NR 0.252
Takata 2007 America Mixed/other 325/250 Mammographically examed Age PCR-RFLP Pre-, post- PB NR 0.104
Onaya 2008 Canada Caucasian 1217/714 Pathologically conformed Age TaqMan Mixed FB Yes 0.832
Onayb 2008 Finland Caucasian 708/549 Pathologically conformed Age TaqMan Mixed FB Yes 0.676
Justenhoven 2008 Germany Caucasian 606/622 NR Age MALDI-TOF MS Mixed PB Yes 0.654
He 2009 America Caucasian 1212/1683 Pathologically conformed Age TaqMan Mixed HB Yes 0.850
Reding 2009 America Caucasian 891/878 NR Age TaqMan post- PB Yes 0.606
GENICA 2009 Germany Caucasian 3144/5481 Histologically conformed Age, region MALDI-TOF MS post- PB Yes 0.094
Yadav 2009 India Asian 154/166 NR Region PCR-RFLP Pre-, post- HB NR 0.570
Shrubsole 2009 China Asian 1093/1169 Pathologically conformed Age PCR-RFLP Pre-, post- PB Yes —
Sangrajrang 2009 Thailand Asian 565/486 Histologically conformed NR TaqMan Mixed HB Yes 0.610
Mónica 2010 Mexico Caucasian 91/94 Pathologically conformed Age, education PCR-RFLP Pre-, post- HB NR 0.669
Syamalaa 2010 India Asian 219/367 Histologically conformed Age PCR-RFLP Mixed PB NR 0.183
Syamalab 2010 India Asian 140/367 Histologically conformed Age PCR-RFLP Mixed FB NR 0.183
Peterson 2010 America Caucasian 1584/1416 Pathologically conformed Age TaqMan Mixed PB Yes 0.026
Delort 2010 France Caucasian 910/1000 Pathologically conformed Age TaqMan Mixed PB Yes 0.230
Wang 2011 China Asian 400/400 Histopathologically conformed Age Sequencing Pre-, post- PB Yes 0.389
Naushad 2011 India Asian 212/233 Histopathologically conformed NR PCR-RFLP Mixed HB NR 0.201
Cribb 2011 Canada Caucasian 207/621 Histopathologically conformed Age PCR-RFLP Mixed HB NR 0.208
Cerne 2011 Slovenia Caucasian 530/270 NR Age TaqMan post- HB Yes 0.903
Lajin 2011 Syria Mixed/other 135/107 Pathologically conformed Age PCR-RFLP Pre-, post- PB NR 0.887
Santos 2011 Brazil Mixed/other 62/62 Pathologically conformed Age PCR-RFLP Pre-, post- PB NR —

PB Population-based FB family-based, HB hospital-based, HWE Hardy–Weinberg equilibrium, NR not reported, Pre- premenopausal, Post- postmenopausal, PCR-RFLP PCR-based restriction fragment length polymorphism, MALDI-TOF MS matrix assisted laser desorption/ionization time-of-flight mass spectrometry, LP Luorescence polarization.

a, b They were two different case–control studies in one publication.

Qin et al. Diagnostic Pathology 2012 7:136   doi:10.1186/1746-1596-7-136

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