Ezrin protein showed significantly higher positivity in gastric adenocarcinoma and dysplasia compared with the adjacent normal gastric mucosa (A), and its expression level was significantly higher in the late stage (Stage II, Stage III, and Stage IV) of gastric cancers than it in the early stage (Stage 0, Stage IA, and Stage IB) cases (B). Moreover, strongly expression of Ezrin protein was detected in Lauren intestinal and diffuse type of gastric adenocarcinomas than it in the mixed type cases (C). Ezrin protein overexpression showed closely correlation to the metastatic status (D) and disease free survival of gastric adenocarcinoma (E).
Jin et al. Diagnostic Pathology 2012 7:135 doi:10.1186/1746-1596-7-135