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Open Access Case Report

Primary pulmonary malignant melanoma: a clinicopathologic study of two cases

Li Gong1, Xiao-Yan Liu1, Wen-Dong Zhang1, Shao-Jun Zhu1, Li Yao1, Xiu-Juan Han1, Miao Lan1, Yan-Hong Li123* and Wei Zhang13*

Author Affiliations

1 The Helmholtz Sino-German Laboratory for Cancer Research, Department of Pathology, Tangdu Hospital, The Fourth Military Medical University, Xi’an, 710038, P.R China

2 Department of Gynaecology and Obstetrics, Tangdu Hospital, the Fourth Military Medical University, Xi’an, 710038, P.R China

3 Department of Pathology, Tangdu Hospital, The Fourth Military Medical University, Xi’an, 710038, P.R China

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Diagnostic Pathology 2012, 7:123  doi:10.1186/1746-1596-7-123

Published: 19 September 2012

Abstract

Malignant melanoma involving the respiratory tract is nearly always metastatic in origin, and primary tumors are very rare. To our knowledge, about 30 cases have been reported in the English literature, one of which involved multiple brain metastases. Here, we report two cases of primary pulmonary malignant melanoma. The first case, which occurred in a 52-year-old Chinese female patient who died 4 months after the initial diagnosis, involved rapid intrapulmonary and intracranial metastases. The second patient, a 65-year-old female, underwent surgical excision, and clinical examination, histopathological characteristics, and immunohistochemical features supported the diagnosis of pulmonary malignant melanoma. No evidence for recurrence and/or metastasis has been found more than one year after the initial surgery. To establish the diagnosis of primary pulmonary malignant melanoma, any extrapulmonary origin must be excluded by detailed examination. Moreover, the tumor should be removed surgically whether it occurs as a single lesion or multiple lesions.

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1480477335765055 webcite.

Keywords:
Primary pulmonary melanoma; Surgical resection; Chemotherapy; Metastasis; Treatment