Adenomyosis-associated perivascular epithelioid cell tumor (PEComa), lymphangioleiomyomatosis, and sclerosing PEComa (x100). (A) An adenomyosis-associated PEComa with ill-defined tumor borders and light eosinophilic tumor cells (arrow). The PEComa was mainly distributed around the adenomyosis (arrowhead). (D) and (G) respectively show that the PEComa was focally positive for HMB-45 and diffusely positive for smooth muscle actin (SMA). (B) Lymphangioleiomyomatosis (LAM) with proliferative spindle cell fascicles in dilated vascular spaces. (E) and (H) respectively show that LAM was focally positive for HMB-45 and diffusely positive for SMA. (C) A sclerosing PEComa with epithelioid tumor cells in a hyalinized extracellular matrix. (F) and (I) respectively show that the sclerosing PEComa was focally positive for HMB-45 and SMA. (A-C, hematoxylin-eosin).
Fang et al. Diagnostic Pathology 2012 7:117 doi:10.1186/1746-1596-7-117