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Open Access Case Report

Malignant transformation of Madelung’s disease in a patient with a coincidental diagnosis of breast cancer: a case report

Maddalena Borriello1, Alessandro Lucidi12, Arnaldo Carbone3, Vito Iannone1 and Gabriella Ferrandina2*

Author Affiliations

1 Department of Oncology, Gynecologic Oncology Unit, Catholic University, Campobasso, Italy

2 Gynecologic Oncology Unit, Catholic University, Rome, Italy

3 Department of Pathology, Catholic University, Campobasso, Italy

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Diagnostic Pathology 2012, 7:116  doi:10.1186/1746-1596-7-116

Published: 1 September 2012

Abstract

Madelung’s disease or multiple symmetric lipomatosis (MSL) is a rare disorder of unknown etiology which typically presents symmetrically subcutaneous accumulation of non-encapsulated adipose tissue which slowly grows around the neck, upper part of the arms, pelvis, back and thigh. This disease is also frequently associated with hepatopathy, glucose intolerance, hyperuricemia, and malignant tumors of the upper airways. Nevertheless, only one description of malignant transformation of Madelung’s disease has been presented in literature. Here, we report a case of liposarcomatous transformation of Madelung’s disease in a 59-year-old Italian woman with a coincidental diagnosis of breast cancer.

The virtual slide for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/3480884087499351 webcite

Keywords:
Madelung disease; Malignant degeneration; Breast cancer