Case Report
Malignant transformation of Madelung’s disease in a patient with a coincidental diagnosis of breast cancer: a case report
1 Department of Oncology, Gynecologic Oncology Unit, Catholic University, Campobasso, Italy
2 Gynecologic Oncology Unit, Catholic University, Rome, Italy
3 Department of Pathology, Catholic University, Campobasso, Italy
Diagnostic Pathology 2012, 7:116 doi:10.1186/1746-1596-7-116
Published: 1 September 2012Abstract
Madelung’s disease or multiple symmetric lipomatosis (MSL) is a rare disorder of unknown etiology which typically presents symmetrically subcutaneous accumulation of non-encapsulated adipose tissue which slowly grows around the neck, upper part of the arms, pelvis, back and thigh. This disease is also frequently associated with hepatopathy, glucose intolerance, hyperuricemia, and malignant tumors of the upper airways. Nevertheless, only one description of malignant transformation of Madelung’s disease has been presented in literature. Here, we report a case of liposarcomatous transformation of Madelung’s disease in a 59-year-old Italian woman with a coincidental diagnosis of breast cancer.
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