Table 1

Associations between SATB1 expression, clinicopathological and molecular parameters in all patients, and patients with colon and rectal cancer
SATB1 Expression Negative Intermediate High
n(%) 307(58.0) 126(23.8) 96(18.1) p-value§
(R)
Age
<=75 208(67.8) 86(68.3) 67(69.8) 0.736
>75 99(32.2) 40(31.7) 29(30.2) (−0.011)
Gender
Female 152(49.5) 71(56.3) 60(62.5) 0.020*
Male 155(50.5) 55(43.7) 36(37.5) (−0.097)
T-stage
1-2 54(18.2) 30(26.1) 24(25.8) 0.350
3 200(67.3) 67(58.3) 52(55.9) (−0.042)
4 43(14.5) 18(15.7) 17(18.3)
missing 10 11 3
N-Stage
0 165(58.1 64(59.8) 55(61.8) 0.719
1 74(26.1) 19(17.8) 21(23.6) (−0.007)
2 45(15.8) 24(22.4) 13(14.6)
missing 23 19 7
M-stage
0 252(83.4) 92(74.2) 85(89.5) 0.977
1 50(16.6) 32(25.8) 10(10.5) (0.036)
missing 5 2 1
Differentiation grade
Intermediate-High 233(77.2) 99(80.5) 70(75.3) 0.964
Low 69(22.8) 24(19.5) 23(24.7) (−0.009)
missing 5 3 3
Vascular invasion
No 89(47.8) 30(46.2) 29(52.7) 0.696
Yes 97(52.2) 35(53.8) 26(47.3) (−0.013)
missing 121 61 41
MSI screening status
MSS 227(78.3) 111(94.9) 87(92.6) <0.001**
MSI 63(21.7) 6(5.1) 7(7.4) (−0.212)
missing 17 11 2
Betacatenin grade
0 99(33.2 37(30.8) 16(16.8) <0.001**
1 105(35.2) 35(29.2) 26(27.4) (0.154)
2 94(31.5) 48(40.0) 53(55.8)
missing 9 6 1
SATB2 expression
negative 125(42.2) 22(11.2) 0(0.0) <0.001**
intermediate 133(44.9) 76(63.9) 41(43.2) (0.392)
high 38(12.8) 21(17.6) 54(56.8)
missing 11 7 1

Category denoted as negative refers to tumours with SATB1 nuclear score (NS) = 0, intermediate to NS 1–3 and strong to NS > 3. § Chi square test for linear trend. R = Spearmans correlation coefficient.The categories marked as not done and unknown were not included in the analysis. *Significant at the 0.05 level. ** Significant at the 0.01 level. N1 = 1-3 positive nodes, N2= > 4 positive nodes. MSS = Microsatellite stable, MSI = Microsatellite unstable. Beta-catenin grade: 0 = score 0–1, 1 = score 2–3, 2 = score 4–5.

Nodin et al.

Nodin et al. Diagnostic Pathology 2012 7:115   doi:10.1186/1746-1596-7-115

Open Data