Additional file 1.

Sample immunohistochemical images of beta-catenin grades. Sample images of beta-catenin staining representing (A) normal colorectal epithelial cells with intact membranous beta-catenin expression, and colorectal cancers with (B) intact membranous expression (grade 1), (C) positive cytoplasmic expression (grade 2), and (D) positive nuclear and cytoplasmic expression (grade 3).

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Nodin et al. Diagnostic Pathology 2012 7:115   doi:10.1186/1746-1596-7-115