NK/T-cell lymphoma of bilateral adrenal glands in a patient with pyothorax
1 Department of Pathology, Sapporo Medical University, South-1, West-17, Chuo-ku, Sapporo, 060-8556, Japan
2 Department of Surgery, Tenshi Hospital, North-12, East-3, Higashi-ku, Sapporo, 065-0012, Japan
3 Division of Clinical Pathology, Sapporo Medical University Hospital, South-1, West-16, Chuo-ku, Sapporo, 060-8543, Japan
Diagnostic Pathology 2012, 7:114 doi:10.1186/1746-1596-7-114Published: 29 August 2012
Primary lymphoma of adrenal glands is rare, and non-B-cell lymphoma associated with pyothorax is also very rare. Here we report the first autopsy case of non-B-cell lymphoma in bilateral adrenal glands of a 79-year-old woman with pyothorax who had an aggressive clinical course. Immunohistochemically, tumor cells showed CD3+, CD45RO+, CD5-, CD7-, CD4-, CD8-, CD10-, CD20-, CD30-, CD79a-, CD138-, CD56-, granzyme B-, TIA-1+ and ALK-. In addition, tumor cells were strongly EBER1-positive by in situ hybridization. In genomic DNA of tumor cells, T-cell receptor rearrangements were not detected by southern blotting. We finally diagnosed this case as extranodal NK/T-cell lymphoma (nasal type).
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