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Resolution: standard / high Figure 2 .
Microscopic features of the case.A. The tumor formed by dense and loose cell regions. The dense regions were composed
of plexiform and nodular oval- to spindle-shaped tumor cells. The loose regions were
composed of fibrosis. Bone trabeculae erosion was observed. B. There were relatively clear boundaries of dense and loose cell regions, both of
which exhibited abundant capillary vessels. Muscle infiltration was confirmed by the
few residual muscle cells in the tumor (arrow). C. The loose region was made up of two components. One was a fibrotic area with fibrinoid
degeneration, and the other was composed of sparse stellate-shaped cells with myxoid
background. D. The large mononucleate cells and multinucleate giant cells were randomly-distributed
among the oval-to-spindle cells, with abundant capillary vessels in the mesenchyme.
The osteoclast-like multinucleate giant cells were abundant and scattered randomly.
E. The oval-to-spindle cells and giant cells aggregated to form non-necrotizing-like
granulomas lesions, with abundant small vascular-formation. F. The sponginess hemangioma regions were also observed in the dense tumor cell nodules.
G. The thick-wall vessels with periendothelial proliferation were congregated in some
areas. This pattern always appeared in the loose region. H. The big vessels showed periendothelial proliferation and protruding into the lumen,
as well. Stellate-shaped cells were sporadically distributed in the loose region.
I. The big thin type of vessel was seen in some areas. (H&E stain. Magnification: A:
10×, B-I: 40×).
Mao et al. Diagnostic Pathology 2012 7:113 doi:10.1186/1746-1596-7-113 |