Table 5

Diagnoses provided by evaluating pathologists and GEP test vs. the reference diagnosis
Case No. Reference Diagnosis Sex GEP EP1 EP2 EP3 EP4 EP5 EP Overall, for 50 case reviews
Result Highest SS H&E Int Final All H&E Int Final All H&E Int Final All H&E Int Final All H&E Int Final All H&E Int All
Case 1 OV F OV 97.6 BR OV OV OV OV OV OV OV OV OV OV OV OV OV OV OV OV -- -- --
Case 2 CO M CO 89.9 CO CO CO CO CO CO CO CO CO PA PA PA CO LU LU LU -- -- --
Case 3 CO M CO 87.6 CO CO CO CO CO CO CO CO CO LU CO CO CO CO CO CO -- -- --
Case 4 BR F BR 97.6 LU OV OV OV LU LU LU BR BR PA PA OV OV PA PA OV OV OV OV -- -- --
Case 5 KI M KI 86.4 KI KI KI KI KI KI KI KI KI LU KI KI KI KI KI KI -- -- --
Case 6 ME F ME 67.4 LY ME ME ME BR BR BR LI ME ME ME BR ME ME ME LU ME ME ME -- -- --
Case 7 BL M BL 45.1 GC PA BL LU GA GA LU LU BL BL LU BL BL BR BL PA PA -- -- --
Case 8 SC M SC 76.1 SC SC SC LI SC SC SC SC SC SC LI ME ME KI LI LI LI -- -- --
Case 9 GA M GA 36.9 GA GA GA SC GA GA GA GA GA GA GA PA PA PA LY GA GA GA -- -- --
Case 10 LU M OV 24.4 BL BL BL BL BL BL BL BL BL BL BL BL BL BL BL BL BL -- -- --
No. incorrect 1 5 3 2 6 4 4 3 2 2 9 5 5 6 4 5 5 29 19 18
No. correct 9 5 7 8 4 6 6 7 8 8 1 5 5 4 6 5 5 21 31 32
% correct 90% 50% 70% 80% 40% 60% 60% 70% 80% 80% 10% 50% 50% 40% 60% 50% 50% 42% 62% 64%

The tumor tissue is indicated by a two-letter code: bladder (BL), breast (BR), colorectal (CO), gastric (GA), testicular germ cell (GC), kidney (KI), hepatocellular (LI), non-small cell lung (LU), non-Hodgkin’s lymphoma (LY), melanoma (ME), ovarian (OV), pancreas (PA), prostate (PR), thyroid (TH) and sarcoma (SC). SS – Similarity Score, a measure of the similarity of the RNA expression pattern of the specimen to the RNA expression pattern of the indicated tissue. Similarity Scores range from 0 (very low similarity) to 100 (very high similarity) and sum to 100 across all 15 tissues on the GEP Test panel. The incorrect predictions are indicated with yellow highlight. Grey indicates no stains ordered.

Kulkarni et al.

Kulkarni et al. Diagnostic Pathology 2012 7:110   doi:10.1186/1746-1596-7-110

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