Table 4

Summary of immunohistochemical results of the 22 cases of extranodal NK/T-cell lymphoma, nasal type

Marker

Total cases

Mostly positive

Partially positive

Overall positivity

Probably negative

Clearly negative

Overall negativity


CD3

22

15 (68%)

5 (23%)

20 (91%)

0

2 (9%)

2 (9%)

CD20

22

0

0

0

0

22 (100%)

22 (100%)

CD5

22

0

2 (9%)

2 (9%)

0

20 (91%)

20 (91%)

CD7

19

5 (26%)

1 (5%)

6 (32%)

1 (5%)

12 (63%)

13 (68%)

CD4

22

0

3 (14%)

3 (14%)

0

19 (86%)

19 (86%)

CD8

22

0

0

0

0

22 (100%)

22 (100%)

βF1

22

0

0

0

0

22 (100%)

22 (100%)

CD56

22

15 (68%)

3 (14%)

18 (82%)

1 (5%)

3 (14%)

4 (18%)

CD57

21

0

0

0

0

21 (100%)

21 (100%)

TIA-1

22

22 (100%)

0

22 (100%)

0

0

0

Granzyme B

22

13 (59%)

8 (36%)

21 (95%)

1 (5%)

0

1 (5%)

Perforin

22

14 (64%)

5 (23%)

19 (86%)

2 (9%)

1 (5%)

3 (14%)

CD45

18

8 (44%)

7 (39%)

15 (83%)

0

3 (17%)

3 (17%)

CD43

22

20 (91%)

2 (9%)

22 (100%)

0

0

0

CD30

20

10 (50%)

5 (25%)

15 (75%)

0

5 (25%)

5 (25%)

ALK

18

0

0

0

0

18 (100%)

18 (100%)

OCT2

20

1 (5%)

4 (20%)

5 (25%)

3 (15%)

12 (60%)

15 (75%)

IRF4/MUM1

15

1 (7%)

4 (27%)

5 (33%)

0

10 (67%)

10 (67%)


Mostly positive = definitely positive on lymphoma cells >50%

Partially positive = 10-50% positive staining

Overall positive = sum of mostly and partially positive results

Probably negative = <10% staining on presumptive lymphoma cells

Clearly negative = clearly negative

Overall negative = sum of probably negative and clearly negative results

Pongpruttipan et al. Diagnostic Pathology 2011 6:79   doi:10.1186/1746-1596-6-79

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