Table 2

Clinical information, morphology, immunophenotype, EBER in situ hybridization, and TCR gene rearrangement of extranodal NK/T-cell lymphoma, nasal type of head and neck region*

No.

Age/Sex

Site (s) of involvement

Symptom (s) and its duration

Basic morphology

CD3

CD5

CD7

CD4

CD8

βF1

CD56

TIA1

GB

PF

CD45

CD30

EBER

TCR gene

Clinical course

1

74/M

Nasal cavity

Rhinorrhea, 1 year

large (A+, N+)

+

-

-

-

-

-

+

+

+

+

+

+

+

I

D, 3 mos

2

40/M

Nasal cavity

Nasal obstruction, 3 mos

medium (A+, N+)

p+

-

-

-

-

-

-

+

p+

p+

-

+

+

I

D, 33 mos

3

31/M

Nasal cavity

Nasal obstruction, 1 mo

large (A+, N+)

p+

-

-

-

-

-

+

+

+

+

+

+

+

-

D, 37 mos

4

37/M

Nasal cavity

Orbital cellulitis, and fever, 2 mos

medium (A-, N+)

p+

-

-

-

-

-

p-

+

p+

+

NA

+

+

-

D, 3 mos

5

41/F

Nasal cavity

Nasal obstruction, 1 mo

small to medium (A+, N+)

+

-

NA

-

-

-

+

+

p+

+

+

NA

+

-

D, 3 mos

6

49/F

Nasal cavity

Nasal obstruction, 2 mos

medium to large (A-, N+)

+

-

+

-

-

-

+

+

+

+

+

p+

+

-

A, 60 mos

7

43/F

Nasal cavity

Nasal obstruction, 2 mos

medium to large (A+, N+)

p+

-

-

p+

-

-

+

+

+

+

-

p+

+

-

D, 8 mos

8

32/M

Nasal cavity

Nasal obstruction, 5 mos

medium to large (A-, N+)

+

-

p-

-

-

-

+

+

p+

p+

NA

-

+

-

D, 3 mos

9

33/M

Nasal cavity

Rhinorrhea, 1 mo

medium (A+, N+)

+

-

+

-

-

-

+

+

p-

p-

p+

+

+

-

D, 4 mos

10

38/M

Nasal cavity

Nasal obstruction with epistaxis, 2 yrs

medium (A+, N+)

+

-

-

-

-

-

p+

+

+

+

+

+

+

I

D, 7 mos

11

48/F

Nasal and oral cavities

Nasal obstruction, 1 mos

medium to large (A+, N+)

+

p+

NA

-

-

-

p+

+

p+

p+

NA

-

+

-

D, 3 mos

12

36/M

Nasal cavity and nasopharynx

Epistaxis with fever, 1 mo

small to medium (A+, N+)

+

-

+

-

-

-

+

+

p+

p-

p+

-

+

-

D, 1 mos

13

26/F

Nasal cavity and nasopharynx

Rhinorrhea, 2 mos

medium (A+, N+)

+

p+

+

-

-

-

+

+

+

+

NA

-

+

-

D, 4 mos

14

42/M

Nasal cavity and nasopharynx

Epistaxis (HIV+), 2 mos

medium to large (A-, N+)

+

-

-

p+

-

-

+

+

+

+

p+

p+

+

-

D, 18 mos

15

41/M

Nasopharynx

Dysphagia, 3 mos

medium (A+, N-)

+

-

-

-

-

-

p+

+

+

+

+

+

+

-

D, 11 mos

16

44/M

Nasopharynx

Rhinorrhea with epistaxis, 6 mos

medium to large (A+, N+)

-

-

-

-

-

-

-

+

p+

-

-

+

+

-

D, 2 mos

17

42/M

Nasopharynx

Nasal obstruction, 1 wk

medium to large (A+, N+)

+

-

+

-

-

-

+

+

+

+

p+

+

+

I

D, 5 mos

18

57/F

Oral cavity

Palatal mass, 2 mos

large (A+, N+)

+

-

-

-

-

-

+

+

+

+

p+

-

+

-

D, 4 mos

19

38/M

Oral cavity

Chronic oral ulcer, 3 mos

medium to large (A-, N+)

+

-

-

-

-

-

-

+

+

p+

+

p+

+

-

D, 3 mos

20

73/M

Base of tongue and larynx

Dysphagia, 2 mos

medium to large (A+, N+)

p+

-

NA

-

-

-

+

+

+

+

p+

NA

+

-

D, 6 mos

21

66/M

Periorbital soft tissue

Orbital cellulitis, 2 wks

medium to large (A+, N+)

-

-

p+

-

-

-

+

+

+

+

p+

+

+

-

D, 3 mos

22

56/M

Periorbital soft tissue

Blurred vision and headache, 2 mos

medium to large (A+, N+)

+

-

-

p+

-

-

+

+

p+

p+

+

p+

+

-

D, 10 mos

* Please see the abbreviations below

For "basic morphology": Large: predominantly (>75%) large cells; Medium to large: mixture of medium-sized to large cells (≥25% each); Medium: predominantly (>75%) medium-sized cells; Small to medium: mixture of small to medium-sized cells (≥25% each); A+: presence of angioinvasion; A-: absence of angioinvasion; N+: presence of tissue necrosis; N-: absence of tissue necrosis

For immunophenotype: GB: granzyme B; PF: perforin; + (mostly positive): positive on lymphoma cells >50%; p+ (partially positive): 10-50% positive; p- (probably negative): <10% staining; - (negative): clearly negative; NA: not available

For TCR gene (PCR -based TCR gene rearrangement analysis); - (negative): no clonal band on polyacrylamide gel electrophoresis and no dominant peak on fluorescence capillary electrophoresis; I: inadequate DNA quality for PCR

For clinical course: A: alive; D: death

Pongpruttipan et al. Diagnostic Pathology 2011 6:79   doi:10.1186/1746-1596-6-79