Table 1 |
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Comparison of the features of well differentiated papillary mesothelioma, mesothelioma of uncertain malignant potential and diffuse malignant mesothelioma arising in tunica vaginalis |
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Well differentiated papillary mesothelioma |
Mesothelioma of uncertain malignant potential |
Diffuse malignant mesothelioma |
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Clinical Presentation |
Hydrocele |
Hydrocele (most often) or scrotal mass (rare) |
Hydrocele or scrotal mass with hemorrhagic fluid |
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Gross |
Single or limited number of small nodules (often pedunculated) |
Single or limited number of small nodules (often pedunculated) |
Diffuse thickening or multinodular growth (larger or irregular nodules) |
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Microscopic Features |
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Papillary architecture |
Yes (exclusive) |
Yes (dominant) |
Yes (focal or rarely dominant) |
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Complex morphology (cribriform, syncitial, solid architecture) |
No |
Focal |
Yes |
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Stromal invasion |
No |
No |
Yes |
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Cell atypia |
No |
No (or mild) |
Yes |
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Mitotic figures |
No (or exceptionally rare) |
No (or exceptionally rare) |
Yes |
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Atypical mitotic figures |
No |
No |
Yes |
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Coagulative necrosis |
No |
No (or microfocal) |
Yes |
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Sarcomatoid growth |
No |
No |
Yes (if present, partial or dominant) |
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Psammoma bodies |
No |
No |
Yes |
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Clinical Behaviour |
Indolent |
Indolent |
Aggressive |
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Trpkov et al. Diagnostic Pathology 2011 6:78 doi:10.1186/1746-1596-6-78 |
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