Table 1

Comparison of the features of well differentiated papillary mesothelioma, mesothelioma of uncertain malignant potential and diffuse malignant mesothelioma arising in tunica vaginalis

Well differentiated papillary mesothelioma

Mesothelioma of uncertain malignant potential

Diffuse malignant mesothelioma


Clinical Presentation

Hydrocele

Hydrocele (most often) or scrotal mass (rare)

Hydrocele or scrotal mass with hemorrhagic fluid

Gross

Single or limited number of small nodules (often pedunculated)

Single or limited number of small nodules (often pedunculated)

Diffuse thickening or multinodular growth (larger or irregular nodules)

Microscopic Features

Papillary architecture

Yes (exclusive)

Yes (dominant)

Yes (focal or rarely dominant)

Complex morphology (cribriform, syncitial, solid architecture)

No

Focal

Yes

Stromal invasion

No

No

Yes

Cell atypia

No

No (or mild)

Yes

Mitotic figures

No (or exceptionally rare)

No (or exceptionally rare)

Yes

Atypical mitotic figures

No

No

Yes

Coagulative necrosis

No

No (or microfocal)

Yes

Sarcomatoid growth

No

No

Yes (if present, partial or dominant)

Psammoma bodies

No

No

Yes

Clinical Behaviour

Indolent

Indolent

Aggressive


Trpkov et al. Diagnostic Pathology 2011 6:78   doi:10.1186/1746-1596-6-78

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