Table 1

Patients with composite histology of atypical Burkitt's and follicular lymphoma

Patient

This case

1

2

3

Age

58

77

52

44

Sex

M

M

F

M

Site and stage at initial presentation

Submand LN + abd LN, ascites

Stage III

Generalized

LN + BM

Stage IV

LN

Stage III

LN + BM

Stage IV

Temporal sequence of transformation

Concomitant

Concomitant

Concomitant

Concomitant

Histology

Composite

Lymphoma

Composite follicular + Burkitt's

Composite Follicular + Burkitt's

Composite Lymphoma

Cytogenetics at transformation

t(14;18) by PCR +

MYC translocation by FISH

t(14;18) + t(8;14)

t(14;18) in follicular area

t(14;18) + t(8;14) in transformed area

t(14;18) + t(8;14)

Treatment

Chemo

Chemo

Chemo → CR

Chemo → CR

Outcome

Primary refractory died 13 months after Dx

Primary refractory and died 4 months after diagnosis

Relapsed 3 months later with partial response to salvage chemo

CNS relapse 6 months later and died

Reference

17

18

19

Abbreviations: F: female; M: male; LN: lymph node; FISH: fluorescent in-situ hybridization; NA: not available; BM: bone marrow;CNS central nervous system;

Dx: diagnosis; CR: complete remission; PR: partial remission; NR: non-remission;

Hwang et al. Diagnostic Pathology 2011 6:63   doi:10.1186/1746-1596-6-63