Histological features of the submandibular lymph node. The histology showed neoplastic follicles and a high grade interfollicular lymphomatous infiltrate featuring starry sky pattern (Figure 2A, × 40 H&E; Figure 2B, × 200 H&E) with frequent mitotic and apoptotic bodies. Immunohistochemical study showed that CD20 is strongly expressed in both the follicular and diffuse components (Figure 2C, H&E × 100), and CD10 is strongly expressed in the follicular component while it is only weakly positive in the interfollicular high grade component (Figure 2D, ×100). The neoplastic follicles are positive for BCL2 (Figure 2E, × 100) and around 95% MIB1 immuno-reactivity is noted in the interfollicular high grade lymphoma infiltrate (Figure 2F, × 100).
Hwang et al. Diagnostic Pathology 2011 6:63 doi:10.1186/1746-1596-6-63